Skip to Main content Skip to Navigation
Book sections

Development of the intestinal immune system in young pigs – role of the microbial environment

Abstract : The intestinal immune system of the neonatal piglet acquires structural and functional competences during the first months of postnatal life. Passive, innate and adaptive immune systems confer appropriate protection from harmful pathogens along with tolerance to ubiquitous dietary antigens and microbiota. The intestinal immune and non-immune barrier as well as microbiota co-develop postnatally. The timing of the developmental pattern of these actors that participate in establishing a homeostatic state in suckling and weaned piglets is described in the current chapter. It is also widely known that maternal diet composition influences colostrum and milk composition, leading to changes in passive immunity transferred to the neonates. Moreover, maternal environment that induces changes in the microbiota of the dam also has huge effects on the gut immune system profile of the offspring. Changes in gut bacterial colonization that are caused by supplementation of gestating and lactating sow diets with prebiotics and by maternal antibiotic treatment, are detailed in relation with their impact on offspring intestinal immune system development and sensitivity to inflammatory challenges. Finally, the long-term impacts of early modifications of offspring gut bacterial colonization are presented to illustrate microbiota-related imprinting of intestinal physiology.
Complete list of metadata

https://hal.inrae.fr/hal-02949566
Contributor : Emilie Bernard <>
Submitted on : Friday, September 25, 2020 - 5:11:13 PM
Last modification on : Tuesday, May 25, 2021 - 9:30:02 AM

Identifiers

Citation

Stéphanie Ferret-Bernard, Isabelle Le Huërou-Luron. Development of the intestinal immune system in young pigs – role of the microbial environment. The suckling and weaned piglet, Wageningen Academic Publishers, pp.159-177, 2020, 978-90-8686-343-3. ⟨10.3920/978-90-8686-894-0_6⟩. ⟨hal-02949566⟩

Share

Metrics

Record views

36