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Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons

Abstract : Background: Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens. The SOS response is a regulatory network under control of the repressor protein LexA targeted at addressing DNA damage, thus promoting genetic variation in times of stress. We recently reported a direct link between the SOS response and the expression of integron integrases in Vibrio cholerae and a plasmid-borne class 1 mobile integron. SOS regulation enhances cassette swapping and capture in stressful conditions, while freezing the integron in steady environments. We conducted a systematic study of available integron integrase promoter sequences to analyze the extent of this relationship across the Bacteria domain.
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https://hal.inrae.fr/hal-02949740
Contributor : Guillaume Cambray <>
Submitted on : Friday, September 25, 2020 - 11:16:13 PM
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Guillaume Cambray, Neus Sanchez-Alberola, Susana Campoy, Émilie Guerin, Sandra da Re, et al.. Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons. Mobile DNA, BioMed Central, 2011, 2 (1), pp.6. ⟨10.1186/1759-8753-2-6⟩. ⟨hal-02949740⟩

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