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Journal Articles (Review Article) Trends in Parasitology Year : 2020

α-Gal-Based Vaccines: Advances, Opportunities, and Perspectives

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Abstract

Humans and crown catarrhines evolved with the inability to synthesize the oligosaccharide galactose-α-1,3-galactose (α-Gal). In turn, they naturally produce high quantities of the glycan-specific antibodies that can be protective against infectious agents exhibiting the same carbohydrate modification on their surface coat. The protective immunity induced by α-Gal is ensured through an antibody-mediated adaptive and cell-mediated innate immune response. Therefore, the α-Gal antigen represents an attractive and feasible target for developing glycan-based vaccines against multiple diseases. In this review article we provide an insight into our current understanding of the mechanisms involved in the protective immunity to α-Gal and discuss the possibilities and challenges in developing a single-antigen pan-vaccine for prevention and control of parasitic diseases of medical and veterinary concern.
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Dates and versions

hal-02951804 , version 1 (21-11-2022)

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Attribution - NonCommercial - CC BY 4.0

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Adnan Hodžić, Lourdes Mateos Hernandez, José de La Fuente, Alejandro Cabezas Cruz. α-Gal-Based Vaccines: Advances, Opportunities, and Perspectives. Trends in Parasitology, 2020, 36 (12), pp.992-1001. ⟨10.1016/j.pt.2020.08.001⟩. ⟨hal-02951804⟩

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