Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA. Cancer J. Clin, 2018. ,
Atmospheric fine particulate matter and breast cancer mortality: A populationbased cohort study, BMJ Open, 2016. ,
Rotating night shifts and risk of breast cancer in women participating in the nurses' health study, J. Natl. Cancer Inst, 2001. ,
Night Shift Work and Risk of Breast Cancer, Current environmental health reports, 2017. ,
Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review, Neuroscience and Biobehavioral Reviews, 2018. ,
Night shift work and breast cancer: a pooled analysis of populationbased case-control studies with complete work history, Eur. J. Epidemiol, 2018. ,
Circadian pathway genetic variation and cancer risk: Evidence from genome-wide association studies, BMC Med, 2018. ,
Loss of circadian clock gene expression is associated with tumor progression in breast cancer, Cell Cycle, vol.13, pp.3282-3291, 2014. ,
PER2 regulation of mammary gland development, Dev, 2018. ,
Reproductive biology of female Bmal1 null mice, Reproduction, 2010. ,
Circadian Clock mutation in dams disrupts nursing behavior and growth of pups, Endocrinology, 2006. ,
Cellular mechano-environment regulates the mammary circadian clock, Nat. Commun, 2017. ,
Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy, Proc. Natl. Acad. Sci. U. S. A, vol.110, pp.12331-12337, 2013. ,
Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice, Curr. Biol, 2015. ,
Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease, Mol. Cell. Biol, vol.12, pp.954-961, 1992. ,
Effects of chronic jet lag on tumor progression in mice, Cancer Res, 2004. ,
Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work, Biochem. Biophys. Res. Commun, 2015. ,
Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice, Physiol. Rep, 2016. ,
Generation of a functional mammary gland from a single stem cell, Nature, 2006. ,
Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases, Am. J. Pathol, issue.10, pp.63568-63575, 2003. ,
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, pp.704-715, 2008. ,
Generation of breast cancer stem cells through epithelial-mesenchymal transition, PLoS One, vol.3, p.2888, 2008. ,
Epithelialmesenchymal transitions: The importance of changing cell state in development and disease, J. Clin. Invest, vol.119, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02912722
Purification and unique properties of mammary epithelial stem cells, Nature, 2006. ,
Mammary stem cells and the differentiation hierarchy: Current status and perspectives, Genes and Development, 2014. ,
A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer, Oncogene, 2014. ,
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo, Cell, pp.961-964, 2002. ,
Identification of valid reference genes for circadian gene-expression studies in human mammary epithelial cells, Chronobiol. Int, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02621939
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes, Cancer Res, 2010. ,
The cellular and molecular origin of tumor-associated macrophages, Science, p.80, 2014. ,
The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer, Hum. Pathol, 2017. ,
Involvement of chemokine receptors in breast cancer metastasis, Nature, 2001. ,
NF-?B promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4, J. Biol. Chem, 2003. ,
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma, Cancer Cell, 2016. ,
Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment, Oncogenesis, 2019. ,
SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor, Br. J. Pharmacol, 2009. ,
A CXCL1 paracrine network links cancer chemoresistance and metastasis, Cell, 2012. ,
Diurnal cortisol rhythm as a predictor of lung cancer survival, Brain. Behav. Immun, 2013. ,
TimeTeller: a New Tool for Precision Circadian Medicine and Cancer Prognosis, bioRxiv, 2019. ,
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells, Nature, vol.525, pp.256-260, 2015. ,
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance, Nature, 2015. ,
Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers, PLoS Genet, 2018. ,
Circadian clock and microarrays: Mammalian genome gets rhythm, Trends in Genetics, 2002. ,
URL : https://hal.archives-ouvertes.fr/hal-00077640
Impaired cholesterol metabolism and enhanced atherosclerosis in clock Mutant Mice, Circulation, 2013. ,
, Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism, 2015.
Circadian influence on metabolism and inflammation in atherosclerosis, Circulation Research, 2016. ,
Circadian disruption leads to insulin resistance and obesity, Curr. Biol, 2013. ,
Circadian dysfunction induces leptin resistance in mice, Cell Metab, 2015. ,
Circadian disruption and dietinduced obesity synergize to promote development of ? -cell failure and diabetes in male rats, Endocrinology, 2015. ,
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis, PLoS Biol, 2004. ,
Remote reprogramming of hepatic circadian transcriptome by breast cancer, Oncotarget, 2017. ,
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis, Cell, vol.165, pp.896-909, 2016. ,
Effects of light and food schedules on liver and tumor molecular clocks in mice, J. Natl. Cancer Inst, 2005. ,
Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing, Cancer Res, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00497206
Circadian Rhythm Disruption Promotes Lung Tumorigenesis, Cell Metab, 2016. ,
Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer, J. Clin. Oncol, 2010. ,
Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer, Oncol. Rep, 2011. ,
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors, Hum. Mol. Genet, 2004. ,
Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina, PLoS One, 2011. ,
Signaling of rat frizzled-2 through phosphodiesterase and cyclic GMP. Science (80-. ), 2002. ,
PDE6 is an effector for the Wnt/Ca 2+ /cGMP-signalling pathway in development, Biochem. Soc. Trans, 2004. ,
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis, Cell, 2019. ,
Defining the Independence of the Liver Circadian Clock, Cell, 2019. ,
Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3?, Mol. Endocrinol, vol.26, pp.1808-1828, 2012. ,
Emerging Biological Principles of Metastasis, Cell, 2017. ,
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions, Nucleic Acids Res, 2005. ,
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers, Proc. Natl. Acad. Sci, 2007. ,
Activin-a signaling promotes epithelialmesenchymal transition, invasion, and metastatic growth of breast cancer, npj Breast Cancer, 2015. ,
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1, Cancer Cell, vol.22, 2012. ,
Stemness of the hybrid epithelial/mesenchymal state in breast cancer and its association with poor survival, Chronobiol. Int, 2013. ,
A matter of time: study of circadian clocks and their role in inflammation, J. Leukoc. Biol, 2016. ,
Clocking in to immunity, Nature Reviews Immunology, 2018. ,
Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action, J. Appl. Physiol, 2011. ,
Posttranscriptional regulation of per1 underlies the oncogenic function of IRE?, Cancer Res, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-02400356
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action, Nat. Med, 2014. ,
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues, Immunity, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02143556
Myeloid-derived suppressor cells as regulators of the immune system, Nature Reviews Immunology, 2009. ,
The immunosuppressive tumour network: Myeloid-derived suppressor cells, regulatory T cells and natural killer T cells, Immunology, 2013. ,
Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNF? and NO-dependent mechanism, promoting a tumor-supportive environment, Oncoimmunology, 2017. ,
Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers, Proc. Natl. Acad. Sci, 2018. ,
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment, Proc. Natl. Acad. Sci, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01791995
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases, Biochimica et Biophysica Acta -Reviews on Cancer, 2019. ,
The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies, J. Leukoc. Biol, 2010. ,
Haematopoietic stem cell release is regulated by circadian oscillations, Nature, 2008. ,
Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice, Blood, 2017. ,
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy, Nature Reviews Immunology, 2017. ,
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer, Proc. Natl. Acad. Sci, 2019. ,
Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma, Front. Oncol, 2018. ,
Characterization of epithelial phenotypes in mortal and immortal human breast cells, Int. J. Cancer, 1992. ,
Accurate transcript quantification from RNA-seq data with or without a reference genome, Bioinformatics: The Impact of Accurate Quantification on Proteomic and Genetic Analysis and Research, 2014. ,
Complex heatmaps reveal patterns and correlations in multidimensional genomic data, Bioinformatics, 2016. ,
mixOmics: An R package for 'omics feature selection and multiple data integration, PLoS Comput. Biol, 2017. ,
, Genome Biol, 2014.
, An R Package for Geneset Enrichment Workflows. bioRxiv, 2019.
, Number of positive tumour infiltrated immune cells for CXCR2 in LD (n=11) and JL (n=8) samples. Data are shown as scatter dot plot with lines representing median with interquartile
, The percentage of disseminated tumour cells in BM and peripheral blood in vehicle (n=4) and SB265610 (n=6) group. Data are presented as scatter dot plot with lines representing median with interquartile. p-values are calculated from an unpaired t-test. (G) Percentage of tumour infiltrating immune cells (TIC) in vehicle (n=5) and SB265610 (n=6) cohort. Data are presented as scatter dot plot with lines representing median with interquartile. p-values are calculated from an unpaired t-test. (H) Relative distribution of lymphoid and myeloid compartment of TIC in both cohorts, Effects of Cxcr2 axis inhibition on tumour development in JL mice: (D) Scheme illustrating the treatment flow
, It increases the proportion of cancer stem cells (CSCs, in dark blue)) and modifies the tumour microenvironment (TME) through the recruitment of myeloid-derived suppressor cells (MDSCs, in yellow) leading to a suppressive tumour immune microenvironment (TIME)