, de caractériser des souches du parasite H.contortus pour leur résistance aux produits anthelminthiques de synthèse, d'une part, et pour leur sensibilité aux tanins condensés d'autre part
, Les souches caractérisées sont majoritairement sensibles à l'ivermectine et au lévamisole et présentent une résistance au thiabendazole. Sur les 5 souches testées, une est résistante à tous les anthelminthiques de synthèse évalués
, Les TC peuvent être utilisés pour lutter contre ces parasites résistants aux anthelminthiques de synthèse, mais avec des efficacités variables. Cette variabilité serait liée à la complexité structurale des tanins condensés et à la présence d'autres composés actifs dans les extraits de plantes, mais aussi à la nature de la résistance des parasites
, Il convient maintenant d'approfondir la compréhension des mécanismes d'action de ces composés en lien avec les caractéristiques de résistance, afin d'optimiser l'utilisation des plantes à tanins condensés en élevage
,
Condensed tannin concentrations of three Lotus species grown in different environments, Chil. J. Agric. Res, vol.68, pp.31-41, 2008. ,
Polyphenols and agriculture: Beneficial effects of proanthocyanidins in forages, Agric. Ecosyst. Environ, vol.75, pp.1-12, 1999. ,
Effect of quebracho-chestnut tannin extracts at 2 dietary crude protein levels on performance, rumen fermentation, and nitrogen partitioning in lactating dairy cows, J. Dairy Sci, vol.99, pp.545-554, 2006. ,
Effect of bioactive compounds from Sainfoin (Onobrychis viciifolia Scop.) on the in vitro larval migration of Haemonchus contortus: role of tannins and flavonol glycosides, Parasitology, vol.131, pp.531-538, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02675036
The kinetics of exsheathment of infective nematode larvae is disturbed in the presence of a tannin-rich plant extract (sainfoin) both in vitro and in vivo, Parasitology, vol.134, pp.1253-1262, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-02656254
Monomers of Condensed Tannins Affect the Larval Exsheathment of Parasitic Nematodes of Ruminants, J. Agric. Food Chem, vol.54, pp.7481-7487, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02663905
, Anthelmintic Resistance in Haemonchus contortus: History, Mechanisms and Diagnosis, 2016.
Fifteen years later, anthelmintic resistances have dramatically spread over goat farms in Guadeloupe, Vet. Parasitol, vol.205, pp.379-384, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02630526
Green tea flavan-3-ols and oligomeric proanthocyanidins inhibit the motility of infective larvae of Teladorsagia circumcincta and Trichostrongylus colubriformis in vitro, Res. Vet. Sci, vol.77, pp.239-243, 2004. ,
, Benefits of Condensed Tannins in Forage Legumes Fed to Ruminants: Importance of Structure, Concentration, and Diet Composition, vol.59, p.861, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02626130
In vitro effect of extracts and purified tannins of sainfoin (Onobrychis viciifolia) against two cattle nematodes, Vet. Parasitol, pp.532-537, 0196. ,
Anthelmintic Activities against Haemonchus contortus or Trichostrongylus colubriformis from Small Ruminants Are Influenced by Structural Features of Condensed Tannins, J. Agric. Food Chem, vol.63, pp.6346-6354, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02637527
Characterization and comparative analysis of the complete Haemonchus contortus b-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes, Int. J. Parasitol, vol.43, pp.465-475, 2013. ,
Anthelminthic resistance of Haemonchus contortus in small ruminants in Switzerland and Southern Germany, 2009. ,
The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus, Genome Biol, vol.14, p.89, 2013. ,
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance? Mol, Biochem. Parasitol, vol.120, pp.297-300, 2002. ,
The occurrence of strains of Haemonchus contortus resistant to thiabendazole, Aust. Vet. J, vol.44, pp.108-109, 1968. ,
A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility, PLoS Negl. Trop, 2010. ,
Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale, The Worminator". Int. J. Parasitol. Drugs Drug Resist, vol.4, pp.233-243, 2014. ,
Anthelmintic resistance detection methods, Vet. Parasitol, vol.103, pp.183-194, 2002. ,
, , vol.121, pp.46-49
Anthelmintic resistance, Vet. Parasitol, vol.72, pp.391-405, 1997. ,
Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes, Vet. Parasitol, vol.144, pp.304-312, 2007. ,
Resistance of Haemonchus contortus to oxfendazole, Aust.Vet. J, vol.55, pp.347-348, 1979. ,
Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus, Mol. Biochem. Parasitol, vol.180, pp.99-105, 2011. ,
Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus, Aust. Vet. J, vol.79, pp.840-842, 2001. ,
Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog, Mol. Biochem. Parasitol, vol.91, pp.327-335, 1998. ,
Activity, Purification, and Analysis of Condensed Tannins: Current State of Affairs and Future Endeavors, Crop Sci, vol.59, p.886, 2019. ,