Nucleotide sequence of the beta-globin genes in gorilla and macaque: The origin of nucleotide polymorphisms in human - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Molecular Evolution Année : 1987

Nucleotide sequence of the beta-globin genes in gorilla and macaque: The origin of nucleotide polymorphisms in human

Résumé

Part of the beta-globin genes ofMacaca cynomolgus andGorilla gorilla has been cloned and sequenced. Ten putatively neutral nucleotide polymorphisms have been described at the beta-globin locus in humans. They are associated in seven combinations, which define seven different haplotypes of the beta-globin gene: four major frameworks—1, 2, 3, and 3*—and three minor frameworks, which we term KI1, KA1, and OR1. The nucleotide sequences of these frameworks are compared with those of homologous sequences in chimpanzee, colobus, macaque, and gorilla. This comparison provides strong evidence that framework 2 was the earliest framework in the human lineage. From framework 2, a rooted parsimonious tree for the six other frameworks is constructed. This phylogenetic tree is discussed in terms of the evolution of nucleotide polymorphisms as well as in terms of genetic affinities between human populations.

Dates et versions

hal-02965502 , version 1 (13-10-2020)

Identifiants

Citer

P. Savatier, G. Trabuchet, Y. Chebloune, C. Faure, G. Verdier, et al.. Nucleotide sequence of the beta-globin genes in gorilla and macaque: The origin of nucleotide polymorphisms in human. Journal of Molecular Evolution, 1987, 24 (4), pp. 309-318. ⟨10.1007/BF02134129⟩. ⟨hal-02965502⟩
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