M. Ackermann, A functional perspective on phenotypic heterogeneity in microorganisms, Nat. Rev. Microbiol, vol.13, pp.497-508, 2015.

M. Z. Anderson, A. C. Gerstein, L. Wigen, J. A. Baller, and J. Berman, Silencing is noisy: population and cell level noise in telomereadjacent genes is dependent on telomere position and sir2, PLoS Genet, vol.10, p.1004436, 2014.

A. Becskei, B. B. Kaufmann, and A. Van-oudenaarden, Contributions of low molecule number and chromosomal positioning to stochastic gene expression, Nat. Genet, vol.37, pp.937-944, 2005.

W. J. Blake, G. Balazsi, M. A. Kohanski, F. J. Isaacs, and K. F. Murphy, Phenotypic consequences of promoter-mediated transcriptional noise, Mol. Cell, vol.24, pp.853-865, 2006.

D. Carmona-gutierrez, T. Eisenberg, S. Buttner, C. Meisinger, and G. Kroemer, Apoptosis in yeast: triggers, pathways, subroutines, Cell Death Differ, vol.17, pp.763-773, 2010.

M. M. Cockell, S. Perrod, and S. M. Gasser, Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae, Genetics, vol.154, pp.1069-1083, 2000.

W. Dang, K. K. Steffen, R. Perry, J. A. Dorsey, and F. B. Johnson, Histone H4 lysine 16 acetylation regulates cellular lifespan, Nature, vol.459, pp.802-807, 2009.

S. S. Dey, J. E. Foley, P. Limsirichai, D. V. Schaffer, and A. P. Arkin, Orthogonal control of expression mean and variance by epigenetic features at different genomic loci, Mol. Syst. Biol, vol.11, p.806, 2015.

B. Fahrenkrog, Histone modifications as regulators of life and death in Saccharomyces cerevisiae, Microb. Cell, vol.3, pp.1-13, 2015.

H. B. Fraser, A. E. Hirsh, G. Giaever, J. Kumm, and M. B. Eisen, Noise minimization in eukaryotic gene expression, PLoS Biol, vol.2, 2004.

G. Giaever, P. Flaherty, J. Kumm, M. Proctor, and C. Nislow, Chemogenomic profiling: identifying the functional interactions of small molecules in yeast, Proc. Natl. Acad. Sci. USA, vol.101, pp.793-798, 2004.

R. A. Greenstein, S. K. Jones, E. C. Spivey, J. R. Rybarski, and I. J. Finkelstein, Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability, vol.7, 2018.

A. J. Griswold, K. T. Chang, A. P. Runko, M. A. Knight, and K. T. Min, , 2008.

, Drosophila. Proc. Natl. Acad. Sci. USA, vol.105, pp.8673-8678

M. Grunstein and S. M. Gasser, Epigenetics in Saccharomyces cerevisiae, Cold Spring Harb. Perspect. Biol, vol.5, p.17491, 2013.

T. A. Hoggard, F. Chang, K. R. Perry, S. Subramanian, and J. Kenworthy, Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins, PLoS Genet, vol.14, 2018.

S. G. Holmes, A. B. Rose, K. Steuerle, E. Saez, and S. Sayegh, Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss, Genetics, vol.145, pp.605-614, 1997.

G. Hornung, R. Bar-ziv, D. Rosin, N. Tokuriki, and D. S. Tawfik, Noise-mean relationship in mutated promoters, Genome Res, vol.22, pp.2409-2417, 2012.

M. Kaeberlein, M. Mcvey, and L. Guarente, The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms, Genes Dev, vol.13, pp.2570-2580, 1999.

C. J. Kenyon, The genetics of ageing, Nature, vol.464, pp.504-512, 2010.

J. Liu, J. M. Francois, and J. P. Capp, Gene Expression Noise Produces Cell-to-Cell Heterogeneity in Eukaryotic Homologous Recombination Rate, Front. Genet, vol.10, p.475, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02174026

J. Liu, H. Martin-yken, F. Bigey, S. Dequin, and J. M. Francois, Natural yeast promoter variants reveal epistasis in the generation of transcriptional-mediated noise and its potential benefit in stressful conditions, Genome Biol. Evol, vol.7, pp.969-984, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01190166

P. Y. Lum, C. D. Armour, S. B. Stepaniants, G. Cavet, and M. K. Wolf, Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes, Cell, vol.116, pp.121-137, 2004.

Y. Mano, T. J. Kobayashi, J. Nakayama, H. Uchida, and M. Oki, Single cell visualization of yeast gene expression shows correlation of epigenetic switching between multiple heterochromatic regions through multiple generations, PLoS Biol, vol.11, p.1001601, 2013.

M. Matecic, S. Stuart, and S. G. Holmes, SIR2-induced inviability is suppressed by histone H4 overexpression, Genetics, vol.162, pp.973-976, 2002.

B. Newcomb and A. Bedalov, Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens, Methods Mol. Biol, vol.548, pp.145-160, 2009.

J. R. Newman, S. Ghaemmaghami, J. Ihmels, D. K. Breslow, and M. Noble, Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise, Nature, vol.441, pp.840-846, 2006.

M. J. Obersriebnig, E. M. Pallesen, K. Sneppen, A. Trusina, and G. Thon, Nucleation and spreading of a heterochromatic domain in fission yeast, Nat. Commun, vol.7, 2016.

A. Raj and A. Van-oudenaarden, nurture, or chance: stochastic gene expression and its consequences, Nature, vol.135, pp.216-226, 2008.

Y. Rawal, R. V. Chereji, H. Qiu, S. Ananthakrishnan, and C. K. Govind, SWI/SNF and RSC cooperate to reposition and evict promoter nucleosomes at highly expressed genes in yeast, Genes Dev, vol.32, pp.695-710, 2018.

H. Renauld, O. M. Aparicio, P. D. Zierath, B. L. Billington, and S. K. Chhablani, Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage, Genes Dev, vol.7, pp.1133-1145, 1993.

A. Sanchez, S. Choubey, and J. Kondev, Regulation of noise in gene expression, Annu. Rev. Biophys, vol.42, pp.469-491, 2013.

A. Sanchez and I. Golding, Genetic determinants and cellular constraints in noisy gene expression, Science, vol.342, pp.1188-1193, 2013.

E. Sharon, D. Van-dijk, Y. Kalma, L. Keren, and O. Manor, Probing the effect of promoters on noise in gene expression using thousands of designed sequences, Genome Res, vol.24, pp.1698-1706, 2014.

J. A. Simon and A. Bedalov, Yeast as a model system for anticancer drug discovery, Nat. Rev. Cancer, vol.4, pp.481-492, 2004.

E. C. Small, L. Xi, J. P. Wang, J. Widom, and J. D. Licht, Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity, Proc. Natl. Acad. Sci. USA, vol.111, pp.2462-2471, 2014.

J. S. Smith, C. B. Brachmann, L. Pillus, and J. D. Boeke, Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p, Genetics, vol.149, pp.1205-1219, 1998.

L. Sussel, D. Vannier, and D. Shore, Epigenetic switching of transcriptional states: cis-and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae, Mol. Cell. Biol, vol.13, pp.3919-3928, 1993.

T. L. To and N. Maheshri, Noise can induce bimodality in positive transcriptional feedback loops without bistability, Science, vol.327, pp.1142-1145, 2010.

S. Uphoff, N. D. Lord, B. Okumus, L. Potvin-trottier, and D. J. Sherratt, Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation, Science, vol.351, pp.1094-1097, 2016.

A. Vendrell, M. Martinez-pastor, A. Gonzalez-novo, A. Pascual-ahuir, and D. A. Sinclair, Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase, EMBO Rep, vol.12, pp.1062-1068, 2011.

J. Viñuelas, G. Kaneko, A. Coulon, E. Vallin, and V. Morin, Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts, BMC Biol, vol.11, p.15, 2013.

L. Weinberger, Y. Voichek, I. Tirosh, G. Hornung, and I. Amit, Expression noise and acetylation profiles distinguish HDAC functions, Mol. Cell, vol.47, pp.193-202, 2012.

E. Y. Xu, K. A. Zawadzki, and J. R. Broach, Single-cell observations reveal intermediate transcriptional silencing states, Mol. Cell, vol.23, pp.219-229, 2006.

J. B. Zaugg and N. M. Luscombe, A genomic model of conditionspecific nucleosome behavior explains transcriptional activity in yeast, 2012.

, Genome Res, vol.22, pp.84-94

Z. Zhang, W. Qian, and J. Zhang, Positive selection for elevated gene expression noise in yeast, Mol. Syst. Biol, vol.5, p.299, 2009.

B. Zoller, D. Nicolas, N. Molina, and F. Naef, Structure of silent transcription intervals and noise characteristics of mammalian genes, Mol. Syst. Biol, vol.11, p.823, 2015.