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Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus

Abstract : Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fi t as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defi ned as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work.
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https://hal.inrae.fr/hal-02972727
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Submitted on : Tuesday, October 20, 2020 - 3:45:10 PM
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Elma Leite, Alberto Oliveira Jr, Fillipe L.R. Do Carmo, Nadia Berkova, Debmalya Barh, et al.. Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus. Anais da Academia Brasileira de Ciências, Academia Brasileira de Ciências, 2020, 92 (suppl 2), ⟨10.1590/0001-3765202020201216⟩. ⟨hal-02972727⟩

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