Merkel cell carcinoma: Changing incidence trends, J. Surg. Oncol, vol.89, pp.1-4, 2005. ,
Merkel Cell Carcinoma: Current United States Incidence and Projected Increases based on Changing Demographics, J. Am. Acad. Derm, 2017. ,
Dramatic Increase in the Incidence and Mortality from Merkel Cell Carcinoma in the United States, Am. Surg, vol.81, pp.802-806, 2015. ,
Merkel cell carcinoma and melanoma: Etiological similarities and differences, Cancer Epidemiol. Biomark. Prev, vol.8, pp.153-158, 1999. ,
Immunosuppression and merkel cell cancer, Transplant. Proc, vol.34, pp.1780-1781, 2002. ,
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma, Science, 2008. ,
Merkel cell carcinoma: Emerging biology, current approaches, and future directions, Am. Soc. Clin. Oncol. Educ. Book. Am. Soc. Clin. Oncol. Meet, 2015. ,
Merkel cell carcinoma of the skin: Pathological and molecular evidence for a causative role of MCV in oncogenesis, J. Pathol, vol.218, pp.48-56, 2009. ,
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration, Int. J. Cancer J. Int. Du Cancer, vol.145, pp.1020-1032, 2019. ,
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator, J. Clin. Investig, vol.121, pp.3623-3634, 2011. ,
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens, J. Virol, vol.84, pp.7064-7072, 2010. ,
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system, J. Am. Acad. Derm, vol.63, pp.751-761, 2010. ,
Merkel cell carcinoma of skin: Diagnosis and management strategies, Drugs Aging, vol.22, pp.219-229, 2005. ,
A comprehensive review of the treatment of Merkel cell carcinoma, Am. J. Clin. Oncol, vol.30, pp.624-636, 2007. ,
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma, N. Engl. J. Med, vol.374, pp.2542-2552, 2016. ,
Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: A multicentre, single-group, open-label, phase 2 trial, Lancet Oncol, 2016. ,
Avelumab: First Global Approval, vol.77, pp.929-937, 2017. ,
Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.37, pp.693-702, 2019. ,
Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma: A Preplanned Interim Analysis of a Clinical Trial, JAMA Oncol, vol.12, pp.919-932, 2018. ,
Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ?1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial, J. Immunother. Cancer, vol.6, issue.7, 2018. ,
Next generation of immune checkpoint therapy in cancer: New developments and challenges, J. Hematol. Oncol, vol.11, p.39, 2018. ,
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy, Semin Cancer Biol, vol.46, pp.65-83, 2017. ,
The state of the art in anti-malarial drug discovery and development, Curr. Top. Med. Chem, vol.11, pp.1226-1254, 2011. ,
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nat. Commun, vol.6, 2015. ,
Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-kappaB activation, J. Endocrinol. Investig, vol.39, pp.83-91, 2016. ,
Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance, Trop. Med. Infect ,
Molecular modes of action of artesunate in tumor cell lines, Mol. Pharm, vol.64, pp.382-394, 2003. ,
The anti-malarial artesunate is also active against cancer, Int. J. Oncol, vol.18, pp.767-773, 2001. ,
Artesunate induces apoptosis and autophagy in HCT116 colon cancer cells, and autophagy inhibition enhances the artesunate-induced apoptosis, Int. J. Mol. Med, vol.42, pp.1295-1304, 2018. ,
Artesunate shows potent anti-tumor activity in B-cell lymphoma, J. Hematol. Oncol, vol.11, issue.23, 2018. ,
Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells, J. Cell. Physiol, vol.227, pp.3778-3786, 2012. ,
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma, Biochem. Biophys. Res. Commun, vol.519, pp.533-539, 2019. ,
Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells, vol.2, pp.517-532, 2015. ,
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis, Redox Biol, vol.11, pp.254-262, 2017. ,
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours, Curr. Drug Discov. Technol, vol.7, pp.37-45, 2010. ,
The antiviral activities of artemisinin and artesunate, Clin. Infect. Dis, vol.47, pp.804-811, 2008. ,
Characterization of functional domains in the Merkel cell polyoma virus Large T antigen, Int. J. Cancer, vol.136, pp.290-300, 2015. ,
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells, Oncotarget, vol.7, pp.32956-32968, 2016. ,
Proliferation-dependent cytotoxicity of anticancer agents: A review, Cancer Res, vol.35, pp.2619-2630, 1975. ,
A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome, Cancer Metastasis Rev, vol.11, pp.919-933, 1992. ,
Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells, PLoS ONE, vol.2, 2007. ,
Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death, Cell Death Differ, vol.19, pp.107-120, 2012. ,
Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death, J. Biol. Chem, vol.278, pp.39176-39184, 2003. ,
The molecular machinery of regulated cell death, Cell Res, vol.29, pp.347-364, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02125072
The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment, Front. Neurosci, vol.13, 2019. ,
, Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, vol.171, pp.273-285, 2017.
Ferroptosis: An iron-dependent form of nonapoptotic cell death, Cell, vol.149, pp.1060-1072, 2012. ,
bafilomycin and cell death: The "a-B-cs" of plecomacrolide-induced neuroprotection, Autophagy, vol.2, pp.228-230, 2006. ,
Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells, Mol. Med. Rep, vol.10, pp.1103-1107, 2014. ,
Ferroptosis is an autophagic cell death process, Cell Res, vol.26, pp.1021-1032, 2016. ,
Ferroptosis is a type of autophagy-dependent cell death, Semin. Cancer Biol, 2019. ,
The ferroptosis inducer erastin irreversibly inhibits system x(c)-and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells, Sci. Rep, vol.8, p.968, 2018. ,
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis, vol.3, 2014. ,
Promoting effect of beta-mercaptoethanol on in vitro development under oxidative stress and cystine uptake of bovine embryos, Biol. Reprod, vol.66, pp.562-567, 2002. ,
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition, Nat. Chem. Biol, vol.13, pp.91-98, 2017. ,
Identification of ACSL4 as a biomarker and contributor of ferroptosis, Biochem. Biophys. Res. Commun, vol.478, pp.1338-1343, 2016. ,
The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma, PLoS ONE, vol.9, 2014. ,
Drug Repositioning in Oncology, Am. J. Ther, 2019. ,
Artemisinin-derived antimalarial endoperoxides from bench-side to bed-side: Chronological advancements and future challenges, Med. Res. Rev, 2020. ,
Time to switch from quinine, Sudan. J. Paediatr, vol.12, pp.6-7, 2012. ,
The activity of Artemisia spp. and their constituents against Trypanosomiasis, Phytomed. Int. J. Phytother. Phytopharm, vol.47, pp.184-191, 2018. ,
Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells, Anticancer Drugs, vol.25, pp.652-662, 2014. ,
Research Progress on Artemisinin and Its Derivatives against Hematological Malignancies, Chin. J. Integr. Med, vol.12, pp.919-934, 2020. ,
Antiviral effects of artesunate on polyomavirus BK replication in primary human kidney cells, Antimicrob. Agents Chemother, vol.58, pp.279-289, 2014. ,
Antiviral effects of artesunate on JC polyomavirus replication in COS-7 cells, Antimicrob. Agents Chemother, vol.58, pp.6724-6734, 2014. ,
Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo, Cancer Res, vol.65, pp.10854-10861, 2005. ,
Ferroptosis and necroinflammation, a yet poorly explored link, Cell Death Differ, vol.26, pp.14-24, 2019. ,
Ferroptosis, a new form of cell death: Opportunities and challenges in cancer, J. Hematol. Oncol, vol.12, 2019. ,
A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer, vol.2, pp.82-90, 2014. ,
A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies, Cancer Chemother. Pharmacol, vol.81, pp.587-596, 2018. ,
Long-term add-on therapy (compassionate use) with oral artesunate in patients with metastatic breast cancer after participating in a phase I study (ARTIC M33/2), Phytomed. Int. J. Phytother. Phytopharm, vol.54, pp.140-148, 2019. ,
Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: New audiological results from a prospective, open, uncontrolled, monocentric phase I study, Cancer Chemother. Pharmacol, vol.77, pp.413-427, 2016. ,
Establishment and characterization of a neuroendocrine skin carcinoma cell line, Lab. Investig, vol.56, pp.302-312, 1987. ,
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma, Int. J. Cancer, vol.101, pp.137-145, 2002. ,
Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice, J. Virol. Methods, vol.187, pp.6-14, 2013. ,