The best COVID-19 predictor is recent smell loss: a cross-sectional study
Richard C. Gerkin
(1)
,
Kathrin Ohla
(2)
,
Maria Geraldine Veldhuizen
(3)
,
Paule V. Joseph
(4)
,
Christine E Kelly
(5)
,
Alyssa J. Bakke
(6)
,
Kimberley E Steele
(4)
,
Robert Pellegrino
(7)
,
Marta y Pepino
(8)
,
Cédric Bouysset
(9)
,
Graciela M Soler
(10)
,
Veronica Pereda-Loth
(11)
,
Michele Dibattista
(12)
,
Keiland Cooper
(13)
,
Ilja Croijmans
(14)
,
Antonella Di Pizio
(15)
,
M. Hakan Ozdener
(16)
,
Anna d'Errico
(17)
,
Florian Ph.S Fischmeister
(18)
,
María Adelaida Bock
(19)
,
Paloma Paloma Domínguez
(20)
,
Hüseyin Yanik
(3)
,
Sanne Boesveldt
(21)
,
Jasper de Groot
(22)
,
Caterina Dinnella
(23)
,
Jessica Freiherr
(24)
,
Tatiana Laktionova
(25)
,
Sajidxa Mariño
(26)
,
Erminio Monteleone
(23)
,
Alexia Nunez-Parra
(27)
,
Olagunju Abdulrahman
(28)
,
Marina Ritchie
(13)
,
Thierry Thomas-Danguin
(29, 30)
,
Julie Walsh-Messinger
(31)
,
Rashid Al Abri
(32)
,
Rafieh Alizadeh
(33)
,
Emmanuelle Bignon
(9)
,
Elena Cantone
(34)
,
Maria Paola Cecchini
(35)
,
Jingguo Chen
(36, 37)
,
Maria Dolors Guàrdia
(38)
,
Kara Hoover
(39)
,
Noam Karni
(40)
,
Marta Navarro
(41)
,
Alissa Nolden
(42)
,
Patricia Portillo Mazal
(43)
,
Nicholas Rowan
(44)
,
Atiye Sarabi-Jamab
(45)
,
Nicholas Archer
(46)
,
Ben Chen
(47)
,
Elizabeth Di Valerio
(48)
,
Emma Feeney
(49)
,
Johannes Frasnelli
(50)
,
Mackenzie Hannum
(16)
,
Claire Hopkins
(51)
,
Hadar Klein
(52)
,
Coralie Mignot
(53)
,
Carla Mucignat
(54)
,
Yuping Ning
(47)
,
Elif Ozturk
(55)
,
Mei Peng
(56)
,
Ozlem Saatci
(57)
,
Elizabeth Sell
(58)
,
Carol Yan
(59)
,
Raul Alfaro
(8)
,
Cinzia Cecchetto
(54)
,
Gérard Coureaud
(60)
,
Riley Herriman
(16)
,
Jeb Justice
(61)
,
Pavan Kumar Kaushik
(62)
,
Sachiko Koyama
(63)
,
Jonathan Overdevest
(64)
,
Nicola Pirastu
(65)
,
Vicente Ramirez
(66)
,
S. Craig Roberts
(67)
,
Barry Smith
(68)
,
Hongyuan Cao
(69)
,
Hong Wang
(16)
,
Patrick Balungwe
(70)
,
Marius Baguma
(70)
,
Maria G Veldhuizen
(3)
,
Michael C Farruggia
(71)
,
Antonella Di Pizio
(72)
,
M Hakan Ozdener
(16)
,
Alexander W Fjaeldstad
(73)
,
Cailu Lin
(16)
,
Mari A Sandell
(74)
,
Preet B Singh
(75)
,
V. Evelyn Evelyn Brindha
(76)
,
Shannon B Olsson
(62)
,
Luis R Saraiva
(77)
,
Gaurav Ahuja
(78)
,
Mohammed K Alwashahi
(32)
,
Surabhi Bhutani
(79)
,
Anna d'Errico
(80)
,
Marco A Fornazieri
(81)
,
Jérôme Golebiowski
(9)
,
Liang-Dar Hwang
(41)
,
Lina Öztürk
(3)
,
Eugeni Roura
(82)
,
Sara Spinelli
(23)
,
Katherine L Whitcroft
(83)
,
Farhoud Faraji
(59)
,
Florian Ph S Fischmeister
(18)
,
Thomas Heinbockel
(84)
,
Julien W Hsieh
(85)
,
Caroline Huart
(86)
,
Iordanis Konstantinidis
(87, 88)
,
Anna Menini
(89)
,
Gabriella Morini
(90)
,
Jonas K Olofsson
,
Carl M Philpott
,
Denis Pierron
(91)
,
Vonnie D C Shields
(92)
,
Vera V Voznessenskaya
(25)
,
Javier Albayay
(54)
,
Aytug Altundag
(93)
,
Moustafa Bensafi
(94)
,
María Adelaida Bock
(19)
,
Orietta Calcinoni
(95)
,
William Fredborg
(90)
,
Christophe Laudamiel
(96)
,
Juyun Lim
(97)
,
Johan N Lundström
(98)
,
Alberto Macchi
(99)
,
Pablo Meyer
(100)
,
Shima T Moein
(45)
,
Enrique Santamaría
(101)
,
Debarka Sengupta
(78)
,
Paloma Rohlfs Dominguez
(20)
,
Hüseyin Yanik
(3)
,
Gccr Group
,
Thomas Hummel
(53)
,
John E Hayes
(6)
,
Danielle R Reed
(16)
,
Masha y Niv
(52)
,
Steven D Munger
(48)
,
Valentina Parma
(102)
1
ASU -
Arizona State University [Tempe]
2 FZJ - Forschungszentrum Jülich GmbH | Centre de recherche de Jülich | Jülich Research Centre
3 Mersin University
4 NIH - National Institutes of Health [Bethesda, MD, USA]
5 AbScent
6 Penn State - Pennsylvania State University
7 University of Tennessee
8 UIUC - University of Illinois at Urbana-Champaign [Urbana]
9 ICN - Institut de Chimie de Nice
10 Universitad de Buenos Aires = University of Buenos Aires [Argentina]
11 AMIS - Anthropologie Moléculaire et Imagerie de Synthèse
12 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
13 UC Irvine - University of California [Irvine]
14 Universiteit Utrecht / Utrecht University [Utrecht]
15 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
16 Monell Chemical Senses Center
17 Goethe-Universität Frankfurt am Main
18 Karl-Franzens-Universität Graz
19 Public Hospital Barrio Obrero - Hospital General de Barrio Obrero [Asunción, Paraguay]
20 UEX - Universidad de Extremadura - University of Extremadura
21 WUR - Wageningen University and Research [Wageningen]
22 Radboud University [Nijmegen]
23 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
24 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
25 A.N. Severtsov Institute of Ecology and Evolution
26 RespiraLibre - Centro de Otorrinolaringología
27 UCHILE - Universidad de Chile = University of Chile [Santiago]
28 FUTA - Federal University of Technology of Akure
29 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
30 UBFC - Université Bourgogne Franche-Comté [COMUE]
31 University of Dayton
32 SQU - Sultan Qaboos University
33 Iran University of Medical Sciences
34 University of Naples Federico II = Università degli studi di Napoli Federico II
35 UNIVR - Università degli studi di Verona = University of Verona
36 Head and Neck Surgery
37 Xjtu - Xi'an Jiaotong University
38 IRTA - Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology
39 UAF - University of Alaska [Fairbanks]
40 Hadassah Hebrew University Medical Center [Jerusalem]
41 USQ - University of Southern Queensland
42 University of Massachusetts
43 Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina]
44 Johns Hopkins University School of Medicine [Baltimore]
45 IPM - Institute for Research in Fundamental Sciences [Tehran]
46 CSIRO - Commonwealth Scientific and Industrial Research Organisation [Australia]
47 GMU - The First Affiliated Hospital of Guangzhou Medical University
48 UF - University of Florida [Gainesville]
49 UCD - University College Dublin [Dublin]
50 UQTR - Université du Québec à Trois-Rivières
51 Guy's and St Thomas' Hospitals
52 HUJ - The Hebrew University of Jerusalem
53 TU Dresden - Technische Universität Dresden = Dresden University of Technology
54 Unipd - Università degli Studi di Padova = University of Padua
55 Kilis Yedi Aralik University
56 University of Otago [Dunedin, Nouvelle-Zélande]
57 Sancaktepe Education and Research Hospital
58 HUP - Hospital of the University of Pennsylvania
59 UC San Diego Health
60 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
61 University ofFlorida
62 Tata Institute of Fundamental Research [Bangalore]
63 Indiana University [Bloomington]
64 CUIMC - Columbia University Irving Medical Center
65 Edin. - University of Edinburgh
66 UC Merced - University of California [Merced]
67 University of Stirling
68 University of London [London]
69 Florida State University [Panama City]
70 Université catholique de Bukavu
71 Yale University [New Haven]
72 Leibniz-Institute for Food Systems Biology at the Technical University of Munich
73 Regional Hospital West Jutland [Denmark]
74 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
75 UiO - University of Oslo
76 Karunya Institute of Technology and Sciences
77 Sidra Medicine [Doha, Qatar]
78 IIIT-Delhi - Indraprastha Institute of Information Technology [New Delhi]
79 School of Exercise and Nutritional Sciences
80 Goethe University Frankfurt
81 State University of Londrina = Universidade Estadual de Londrina
82 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
83 UCL - University College of London [London]
84 Howard University College of Medicine
85 Geneva University Hospitals, Geneva University , Geneva , Switzerland.
86 Cliniques Universitaires Saint-Luc [Bruxelles]
87 General Hospital Papageorgiou
88 Aristotle University of Thessaloniki
89 SISSA / ISAS - Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies
90 Stockholm University
91 UT - Université de Toulouse
92 Towson University [Towson, MD, United States]
93 Biruni University
94 Lyon Neuroscience Research center
95 Private practice [Milan]
96 DreamAir Llc
97 OSU - Oregon State University
98 Karolinska Institutet [Stockholm]
99 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
100 IBM T.J. Watson Research Center
101 Navarrabiomed-IdiSNA
102 Temple University
2 FZJ - Forschungszentrum Jülich GmbH | Centre de recherche de Jülich | Jülich Research Centre
3 Mersin University
4 NIH - National Institutes of Health [Bethesda, MD, USA]
5 AbScent
6 Penn State - Pennsylvania State University
7 University of Tennessee
8 UIUC - University of Illinois at Urbana-Champaign [Urbana]
9 ICN - Institut de Chimie de Nice
10 Universitad de Buenos Aires = University of Buenos Aires [Argentina]
11 AMIS - Anthropologie Moléculaire et Imagerie de Synthèse
12 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
13 UC Irvine - University of California [Irvine]
14 Universiteit Utrecht / Utrecht University [Utrecht]
15 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
16 Monell Chemical Senses Center
17 Goethe-Universität Frankfurt am Main
18 Karl-Franzens-Universität Graz
19 Public Hospital Barrio Obrero - Hospital General de Barrio Obrero [Asunción, Paraguay]
20 UEX - Universidad de Extremadura - University of Extremadura
21 WUR - Wageningen University and Research [Wageningen]
22 Radboud University [Nijmegen]
23 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
24 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
25 A.N. Severtsov Institute of Ecology and Evolution
26 RespiraLibre - Centro de Otorrinolaringología
27 UCHILE - Universidad de Chile = University of Chile [Santiago]
28 FUTA - Federal University of Technology of Akure
29 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
30 UBFC - Université Bourgogne Franche-Comté [COMUE]
31 University of Dayton
32 SQU - Sultan Qaboos University
33 Iran University of Medical Sciences
34 University of Naples Federico II = Università degli studi di Napoli Federico II
35 UNIVR - Università degli studi di Verona = University of Verona
36 Head and Neck Surgery
37 Xjtu - Xi'an Jiaotong University
38 IRTA - Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology
39 UAF - University of Alaska [Fairbanks]
40 Hadassah Hebrew University Medical Center [Jerusalem]
41 USQ - University of Southern Queensland
42 University of Massachusetts
43 Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina]
44 Johns Hopkins University School of Medicine [Baltimore]
45 IPM - Institute for Research in Fundamental Sciences [Tehran]
46 CSIRO - Commonwealth Scientific and Industrial Research Organisation [Australia]
47 GMU - The First Affiliated Hospital of Guangzhou Medical University
48 UF - University of Florida [Gainesville]
49 UCD - University College Dublin [Dublin]
50 UQTR - Université du Québec à Trois-Rivières
51 Guy's and St Thomas' Hospitals
52 HUJ - The Hebrew University of Jerusalem
53 TU Dresden - Technische Universität Dresden = Dresden University of Technology
54 Unipd - Università degli Studi di Padova = University of Padua
55 Kilis Yedi Aralik University
56 University of Otago [Dunedin, Nouvelle-Zélande]
57 Sancaktepe Education and Research Hospital
58 HUP - Hospital of the University of Pennsylvania
59 UC San Diego Health
60 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
61 University ofFlorida
62 Tata Institute of Fundamental Research [Bangalore]
63 Indiana University [Bloomington]
64 CUIMC - Columbia University Irving Medical Center
65 Edin. - University of Edinburgh
66 UC Merced - University of California [Merced]
67 University of Stirling
68 University of London [London]
69 Florida State University [Panama City]
70 Université catholique de Bukavu
71 Yale University [New Haven]
72 Leibniz-Institute for Food Systems Biology at the Technical University of Munich
73 Regional Hospital West Jutland [Denmark]
74 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
75 UiO - University of Oslo
76 Karunya Institute of Technology and Sciences
77 Sidra Medicine [Doha, Qatar]
78 IIIT-Delhi - Indraprastha Institute of Information Technology [New Delhi]
79 School of Exercise and Nutritional Sciences
80 Goethe University Frankfurt
81 State University of Londrina = Universidade Estadual de Londrina
82 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
83 UCL - University College of London [London]
84 Howard University College of Medicine
85 Geneva University Hospitals, Geneva University , Geneva , Switzerland.
86 Cliniques Universitaires Saint-Luc [Bruxelles]
87 General Hospital Papageorgiou
88 Aristotle University of Thessaloniki
89 SISSA / ISAS - Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies
90 Stockholm University
91 UT - Université de Toulouse
92 Towson University [Towson, MD, United States]
93 Biruni University
94 Lyon Neuroscience Research center
95 Private practice [Milan]
96 DreamAir Llc
97 OSU - Oregon State University
98 Karolinska Institutet [Stockholm]
99 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
100 IBM T.J. Watson Research Center
101 Navarrabiomed-IdiSNA
102 Temple University
Richard C. Gerkin
- Fonction : Auteur
- PersonId : 801990
- ORCID : 0000-0002-2940-3378
Kathrin Ohla
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- PersonId : 801989
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Cédric Bouysset
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Veronica Pereda-Loth
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Ilja Croijmans
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Jessica Freiherr
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Thierry Thomas-Danguin
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Rafieh Alizadeh
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Claire Hopkins
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Gérard Coureaud
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Hong Wang
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Michael C Farruggia
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- ORCID : 0000-0002-5306-6754
Alexander W Fjaeldstad
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Cailu Lin
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Luis R Saraiva
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Gaurav Ahuja
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Jérôme Golebiowski
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Eugeni Roura
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Jonas K Olofsson
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Carl M Philpott
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Denis Pierron
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Moustafa Bensafi
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Alberto Macchi
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Debarka Sengupta
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Paloma Rohlfs Dominguez
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Gccr Group
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Thomas Hummel
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Valentina Parma
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Résumé
Background: COVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19. Methods: This preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery. Results: Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing no significant model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ~50% of participants and was best predicted by time since illness onset. Conclusions: As smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (10
| Origine | Fichiers produits par l'(les) auteur(s) |
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https://hal.inrae.fr/hal-02979656
Soumis le : mardi 27 octobre 2020-11:35:13
Dernière modification le : vendredi 20 décembre 2024-11:38:18
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Identifiants
- HAL Id : hal-02979656 , version 2
- DOI : 10.1101/2020.07.22.20157263
- PUBMED : 32743605
- PUBMEDCENTRAL : PMC7386529
Citer
Richard C. Gerkin, Kathrin Ohla, Maria Geraldine Veldhuizen, Paule V. Joseph, Christine E Kelly, et al.. The best COVID-19 predictor is recent smell loss: a cross-sectional study. 2020. ⟨hal-02979656v2⟩
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