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Impact of porcine circovirus type 2 (PCV2) infection on hepatitis E virus (HEV) infection and transmission under experimental conditions Morgane Salines 97cc25bcde2c4ebe337060572c356f7c anses.fr msalines 1662339 1034074-1662339 https://orcid.org/0000-0002-6821-4131 Mathieu Andraud adb7ef55b95a5e5fe69beebf581159cb afssa.fr mathieu-andraud 983095 695020-983095 https://orcid.org/0000-0003-2891-2901 https://www.idref.fr/13218060X https://viaf.org/viaf/216329872 http://isni.org/isni/0000000359291722 Marie Pellerin 1509638-0 Cécilia Bernard 1837252-0 Béatrice Grasland 2fc84541b8991fd32f3e63dd727e86dd afssa.fr beatrice-grasland 1019755 406100-1019755 https://orcid.org/0000-0001-5777-673X https://viaf.org/viaf/210035902 http://isni.org/isni/0000000140217405 https://www.idref.fr/071070958 Nicole Pavio 5d2fe3453616722713c968ae946c55fd anses.fr nicole-pavio 1203572 744306-1203572 https://www.idref.fr/167623265 https://orcid.org/0000-0001-6703-9418 Nicolas Rose 57a7a4ada9affe867ba49ce48fa3197c anses.fr nicolas-rose 983097 775790-983097 https://www.idref.fr/263570614 https://orcid.org/0000-0001-8789-2395 https://orcid.org/0000-0003-1327-621X Accord Elsevier CCSD 3cc0cc7b8e3329bfb7423fa2578d788e ccsd.cnrs.fr INAPORC French Ministry for Agriculture and Food 2021-10-22 21:44:36 2026-04-20 14:36:19 2021-10-22 21:44:38 2019-07 2020-05-15 0 inra_etatDocument_local_0 inra_publicVise_local_SC contributor Accord Elsevier CCSD 3cc0cc7b8e3329bfb7423fa2578d788e ccsd.cnrs.fr CCSD hal-02981988 https://hal.inrae.fr/hal-02981988 salines:hal-02981988 <i>Veterinary Microbiology</i>, 2019, 234, pp.1-7. <a target="_blank" href="https://dx.doi.org/10.1016/j.vetmic.2019.05.010">⟨10.1016/j.vetmic.2019.05.010⟩</a> Veterinary Microbiology, 2019, 234, pp.1-7. ⟨10.1016/j.vetmic.2019.05.010⟩ CC BY-NC 4.0 - Attribution - Non-commercial use Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail INRA - Institut national de la recherche agronomique Archive ouverte en agrobiosciences Ecole Nationale Vétérinaire d'Alfort Institut National de Recherche en Agriculture, Alimentation et Environnement Import Elsevier Virologie - Maladies animales, zoonoses et risques infectieux Département Santé Animale International No Yes Impact of porcine circovirus type 2 (PCV2) infection on hepatitis E virus (HEV) infection and transmission under experimental conditions Morgane Salines 97cc25bcde2c4ebe337060572c356f7c anses.fr msalines 1662339 1034074-1662339 https://orcid.org/0000-0002-6821-4131 Mathieu Andraud adb7ef55b95a5e5fe69beebf581159cb afssa.fr mathieu-andraud 983095 695020-983095 https://orcid.org/0000-0003-2891-2901 https://www.idref.fr/13218060X https://viaf.org/viaf/216329872 http://isni.org/isni/0000000359291722 Marie Pellerin 1509638-0 Cécilia Bernard 1837252-0 Béatrice Grasland 2fc84541b8991fd32f3e63dd727e86dd afssa.fr beatrice-grasland 1019755 406100-1019755 https://orcid.org/0000-0001-5777-673X https://viaf.org/viaf/210035902 http://isni.org/isni/0000000140217405 https://www.idref.fr/071070958 Nicole Pavio 5d2fe3453616722713c968ae946c55fd anses.fr nicole-pavio 1203572 744306-1203572 https://www.idref.fr/167623265 https://orcid.org/0000-0001-6703-9418 Nicolas Rose 57a7a4ada9affe867ba49ce48fa3197c anses.fr nicolas-rose 983097 775790-983097 https://www.idref.fr/263570614 https://orcid.org/0000-0001-8789-2395 https://orcid.org/0000-0003-1327-621X 19836 0378-1135 Veterinary Microbiology Elsevier 234 1-7 2019-07 10.1016/j.vetmic.2019.05.010 S0378-1135(19)30243-3 31213264 000474681700001 English Transmission experiment Co-infection PCV2 HEV Infection kinetic Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Journal articles Journal articles Journal articles

Hepatitis E virus is a zoonotic pathogen for which pigs have been identified as the main reservoir in industrialised countries. HEV infection dynamics in pig herds and pigs are influenced by several factors, including herd practices and possibly co-infection with immunomodulating viruses. This study therefore investigates the impact of porcine circovirus type 2 (PCV2) on HEV infection and transmission through experimental HEV/PCV2 co-infection of specific-pathogen-free pigs. No statistical difference between HEV-only and HEV/PCV2-infected animals was found for either the infectious period or the quantity of HEV shed in faeces. The HEV latency period was shorter for HEV/PCV2 co-infected pigs than for HEV-only infected pigs (11.6 versus 12.3 days). Its direct transmission rate was three times higher in cases of HEV/PCV2 co-infection than in cases of HEV-only infection (0.12 versus 0.04). On the other hand, the HEV transmission rate through environmental accumulation was lower in cases of HEV/PCV2 co-infection (4.3.10(-6) versus 1.5.10(-5) g/RNA copies/day for HEV-only infected pigs). The time prior to HEV seroconversion was 1.9 times longer in HEV/PCV2 co-infected pigs (49.4 versus 25.6 days for HEV-only infected pigs). In conclusion, our study shows that PCV2 affects HEV infection and transmission in pigs under experimental conditions.

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