M. M. Matzuk, K. H. Burns, M. M. Viveiros, and J. J. Eppig, Intercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation, Science, vol.296, issue.5576, pp.2178-2180, 2002.

R. Dalbies-tran, V. Cadoret, A. Desmarchais, S. Elis, V. Maillard et al., A Comparative Analysis of Oocyte Development in Mammals, Cells, vol.9, issue.4, p.1002, 2020.
URL : https://hal.archives-ouvertes.fr/hal-02545852

A. D. Macaulay, I. Gilbert, J. Caballero, R. Barreto, E. Fournier et al., The Gametic Synapse: RNA Transfer to the Bovine Oocyte1, Biology of Reproduction, vol.91, issue.4, p.90, 2014.

D. Pietro and C. , Exosome-mediated communication in the ovarian follicle, Journal of Assisted Reproduction and Genetics, vol.33, issue.3, pp.303-311, 2016.

M. D. Collado, G. M. Andrade, F. V. Meirelles, J. C. Silveira, and F. Perecin, Contributions from the ovarian follicular environment to oocyte function, Animal Reproduction, vol.15, issue.3, pp.261-270, 2018.

D. Tesfaye, T. Hailay, D. Salilew-wondim, M. Hoelker, S. Bitseha et al., Extracellular vesicle mediated molecular signaling in ovarian follicle: Implication for oocyte developmental competence, Theriogenology, vol.150, pp.70-74, 2020.

M. Yanez-mo, P. R. Siljander, Z. Andreu, A. B. Zavec, F. E. Borras et al., Biological properties of extracellular vesicles and their physiological functions, J Extracell Vesicles, vol.4, p.27066, 2015.

R. Machtinger, L. C. Laurent, and A. A. Baccarelli, Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation, Human Reproduction Update, vol.22, p.dmv055, 2015.

G. Burns, K. Brooks, M. Wildung, R. Navakanitworakul, L. K. Christenson et al., Extracellular Vesicles in Luminal Fluid of the Ovine Uterus, PLoS ONE, vol.9, issue.3, p.e90913, 2014.

C. Almiñana, E. Corbin, G. Tsikis, A. S. Alcântara-neto, V. Labas et al., Oviduct extracellular vesicles protein content and their role during oviduct?embryo cross-talk, Reproduction, vol.154, issue.3, pp.253-268, 2017.

J. C. Da-silveira, A. C. De-Ávila, H. L. Garrett, J. E. Bruemmer, Q. A. Winger et al., Cell-secreted vesicles containing microRNAs as regulators of gamete maturation, Journal of Endocrinology, vol.236, issue.1, pp.R15-R27, 2018.

F. B. Almughlliq, Y. Q. Koh, H. N. Peiris, K. Vaswani, O. Holland et al., Circulating exosomes may identify biomarkers for cows at risk for metabolic dysfunction, Scientific Reports, vol.9, issue.1, p.13879, 2019.

E. Giacomini, S. Makieva, V. Murdica, R. Vago, and P. Viganó, Extracellular vesicles as a potential diagnostic tool in assisted reproduction, Current Opinion in Obstetrics and Gynecology, vol.32, issue.3, pp.179-184, 2020.

W. T. Hung, R. Navakanitworakul, T. Khan, P. Zhang, J. S. Davis et al., Stage-specific follicular extracellular vesicle uptake and regulation of bovine granulosa cell proliferation?, Biology of Reproduction, vol.97, issue.4, pp.644-655, 2017.

W. T. Hung, X. Hong, L. K. Christenson, and L. K. Mcginnis, Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion1, Biology of Reproduction, vol.93, issue.5, p.117, 2015.

J. C. Da-silveira, G. M. Andrade, M. Del-collado, R. V. Sampaio, J. R. Sangalli et al., Supplementation with small-extracellular vesicles from ovarian follicular fluid during in vitro production modulates bovine embryo development, PLOS ONE, vol.12, issue.6, p.e0179451, 2017.

A. C. De-Ávila, A. Bridi, G. M. Andrade, M. Del-collado, J. R. Sangalli et al., Estrous cycle impacts microRNA content in extracellular vesicles that modulate bovine cumulus cell transcripts during in vitro maturation?, Biology of Reproduction, vol.102, issue.2, pp.362-375, 2019.

T. A. Rodrigues, K. M. Tuna, A. A. Alli, P. Tribulo, P. J. Hansen et al., Follicular fluid exosomes act on the bovine oocyte to improve oocyte competence to support development and survival to heat shock, Reproduction, Fertility and Development, vol.31, issue.5, p.888, 2019.

J. S. Lopes, A. Canha-gouveia, E. París-oller, and P. Coy, Supplementation of bovine follicular fluid during in vitro maturation increases oocyte cumulus expansion, blastocyst developmental kinetics, and blastocyst cell number, Theriogenology, vol.126, pp.222-229, 2019.

J. C. Da-silveira, D. N. Veeramachaneni, Q. A. Winger, E. M. Carnevale, and G. J. Bouma, Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle1, Biology of Reproduction, vol.86, issue.3, p.71, 2012.

M. M. Sohel, M. Hoelker, S. S. Noferesti, D. Salilew-wondim, E. Tholen et al., Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence, PLoS ONE, vol.8, issue.11, p.e78505, 2013.

S. S. Noferesti, M. M. Sohel, M. Hoelker, D. Salilew-wondim, E. Tholen et al., Controlled ovarian hyperstimulation induced changes in the expression of circulatory miRNA in bovine follicular fluid and blood plasma, Journal of Ovarian Research, vol.8, issue.1, p.81, 2015.

R. Navakanitworakul, W. T. Hung, S. Gunewardena, J. S. Davis, W. Chotigeat et al., Characterization and Small RNA Content of Extracellular Vesicles in Follicular Fluid of Developing Bovine Antral Follicles, Scientific Reports, vol.6, issue.1, p.25486, 2016.

T. Hailay, M. Hoelker, M. Poirier, S. Gebremedhn, F. Rings et al., Extracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status, Scientific Reports, vol.9, issue.1, p.12851, 2019.

H. Kalra, R. J. Simpson, H. Ji, E. Aikawa, P. Altevogt et al., Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation, PLoS Biology, vol.10, issue.12, p.e1001450, 2012.

M. Pathan, P. Fonseka, S. V. Chitti, T. Kang, R. Sanwlani et al., Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles, Nucleic Acids Research, vol.47, issue.D1, pp.D516-D519, 2018.

M. A. Crookenden, C. G. Walker, H. Peiris, Y. Koh, F. Almughlliq et al., Effect of circulating exosomes from transition cows on Madin-Darby bovine kidney cell function, Journal of Dairy Science, vol.100, issue.7, pp.5687-5700, 2017.

Y. Q. Koh, H. N. Peiris, K. Vaswani, S. Meier, C. R. Burke et al., Characterization of exosomes from body fluids of dairy cows, Journal of Animal Science, vol.95, issue.9, p.3893, 2017.

H. Li, X. Huang, X. Chang, J. Yao, Q. He et al., S100?A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF??B pathway in polycystic ovary syndrome, Journal of Cellular and Molecular Medicine, vol.24, issue.1, pp.114-125, 2020.

A. S. Alcântara-neto, M. Fernandez-rufete, E. Corbin, G. E. Tsikis, R. Uzbekov et al., Oviduct fluid extracellular vesicles regulate polyspermy during porcine in vitro fertilisation, Reproduction, Fertility and Development, vol.32, issue.4, p.409, 2020.

A. S. Alcântara-neto, L. Schmaltz, E. Caldas, M. C. Blache, P. Mermillod et al., Porcine oviductal extracellular vesicles interact with gametes and regulate sperm motility and survival, Theriogenology, vol.155, pp.240-255, 2020.

C. Théry, S. Amigorena, G. Raposo, and A. Clayton, Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids, Current Protocols in Cell Biology, vol.30, issue.1, pp.3.22.1-3.22.29, 2006.

S. Kenigsberg, B. A. Wyse, C. L. Librach, and J. C. Da-silveira, Protocol for Exosome Isolation from Small Volume of Ovarian Follicular Fluid: Evaluation of Ultracentrifugation and Commercial Kits, Methods in Molecular Biology, vol.1660, pp.321-341, 2017.

C. Almiñana, G. Tsikis, V. Labas, R. Uzbekov, J. C. Da-silveira et al., Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo, BMC Genomics, vol.19, issue.1, p.622, 2018.

M. Salhab, L. Tosca, C. Cabau, P. Papillier, C. Perreau et al., Kinetics of gene expression and signaling in bovine cumulus cells throughout IVM in different mediums in relation to oocyte developmental competence, cumulus apoptosis and progesterone secretion, Theriogenology, vol.75, issue.1, pp.90-104, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01129418

V. Labas, I. Grasseau, K. Cahier, A. Gargaros, G. Harichaux et al., Qualitative and quantitative peptidomic and proteomic approaches to phenotyping chicken semen, Journal of Proteomics, vol.112, pp.313-335, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01129861

A. Keller, A. I. Nesvizhskii, E. Kolker, and R. Aebersold, Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search, Analytical Chemistry, vol.74, issue.20, pp.5383-5392, 2002.

A. I. Nesvizhskii, A. Keller, E. Kolker, and R. Aebersold, A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry, Analytical Chemistry, vol.75, issue.17, pp.4646-4658, 2003.

E. W. Deutsch, C. M. Overall, J. E. Van-eyk, M. S. Baker, Y. K. Paik et al., Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 2.1, Journal of Proteome Research, vol.15, issue.11, pp.3961-3970, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02191414

P. S. Bertevello, A. P. Teixeira-gomes, A. Seyer, A. Vitorino-carvalho, V. Labas et al., Lipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle, International Journal of Molecular Sciences, vol.19, issue.10, p.3261, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02628741

W. F. Marei, G. Van-raemdonck, G. Baggerman, P. E. Bols, and J. L. Leroy, Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells, Scientific Reports, vol.9, issue.1, p.3673, 2019.

K. Gegenfurtner, F. Flenkenthaler, T. Fröhlich, E. Wolf, and G. J. Arnold, The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes?, Biology of Reproduction, vol.103, issue.5, pp.1000-1011, 2020.

M. Pathan, S. Keerthikumar, C. S. Ang, L. Gangoda, C. Y. Quek et al., FunRich: An open access standalone functional enrichment and interaction network analysis tool, PROTEOMICS, vol.15, issue.15, pp.2597-2601, 2015.

T. A. Reinhardt, J. D. Lippolis, B. J. Nonnecke, and R. E. Sacco, Bovine milk exosome proteome, Journal of Proteomics, vol.75, issue.5, pp.1486-1492, 2012.

J. Walter, C. Monthoux, C. Fortes, J. Grossmann, B. Roschitzki et al., The bovine cumulus proteome is influenced by maturation condition and maturational competence of the oocyte, Scientific Reports, vol.10, issue.1, p.9880, 2020.

M. Grzesiak, K. Popiolek, and K. Knapczyk-stwora, Extracellular vesicles in follicular fluid of sexually mature gilts' ovarian antral folliclesidentification and proteomic analysis, J. Physiol. Pharmacol, vol.71, pp.137-180, 2020.

S. Fahiminiya, V. Labas, S. Roche, J. L. Dacheux, and N. Gérard, Proteomic analysis of mare follicular fluid during late follicle development, Proteome Science, vol.9, issue.1, p.54, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01129526

H. Sork, G. Corso, K. Krjutskov, H. J. Johansson, J. Z. Nordin et al., Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome, Scientific Reports, vol.8, issue.1, p.10813, 2018.

X. Chen, J. Zhou, X. Li, X. Wang, Y. Lin et al., Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype, Cancer Letters, vol.435, pp.80-91, 2018.

J. A. Loukides, R. A. Loy, R. Edwards, J. Honig, I. Visintin et al., Human Follicular Fluids Contain Tissue Macrophages*, The Journal of Clinical Endocrinology & Metabolism, vol.71, issue.5, pp.1363-1367, 1990.

S. B. Serizier and K. Mccall, Scrambled Eggs: Apoptotic Cell Clearance by Non-Professional Phagocytes in the Drosophila Ovary, Frontiers in Immunology, vol.8, p.1642, 2017.

Y. Zhu, X. Chen, Q. Pan, Y. Wang, S. Su et al., A Comprehensive Proteomics Analysis Reveals a Secretory Path- and Status-Dependent Signature of Exosomes Released from Tumor-Associated Macrophages, Journal of Proteome Research, vol.14, issue.10, pp.4319-4331, 2015.

R. C. Lai, S. S. Tan, B. J. Teh, S. K. Sze, F. Arslan et al., Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome, International Journal of Proteomics, vol.2012, pp.1-14, 2012.

K. Tanaka, The proteasome: Overview of structure and functions, Proceedings of the Japan Academy, Series B, vol.85, issue.1, pp.12-36, 2009.

R. L. Robker, J. D. Hennebold, and D. L. Russell, Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time, Endocrinology, vol.159, issue.9, pp.3209-3218, 2018.

K. O?brien, K. Breyne, S. Ughetto, L. C. Laurent, and X. O. Breakefield, RNA delivery by extracellular vesicles in mammalian cells and its applications, Nature Reviews Molecular Cell Biology, vol.21, issue.10, pp.585-606, 2020.

L. Statello, M. Maugeri, E. Garre, M. Nawaz, J. Wahlgren et al., Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes, PLOS ONE, vol.13, issue.4, p.e0195969, 2018.

Y. Ogawa, M. Tsujimoto, and R. Yanoshita, Next-Generation Sequencing of Protein-Coding and Long Non-protein-Coding RNAs in Two Types of Exosomes Derived from Human Whole Saliva, Biological & Pharmaceutical Bulletin, vol.39, issue.9, pp.1496-1507, 2016.

M. S. Miranda, H. S. Nascimento, M. P. Costa, N. N. Costa, K. N. Brito et al., Increasing of blastocyst rate and gene expression in co-culture of bovine embryos with adult adipose tissue-derived mesenchymal stem cells, Journal of Assisted Reproduction and Genetics, vol.33, issue.10, pp.1395-1403, 2016.

D. K. Jeppesen, A. M. Fenix, J. L. Franklin, J. N. Higginbotham, Q. Zhang et al., Reassessment of Exosome Composition, Cell, vol.177, issue.2, pp.428-445.e18, 2019.

J. Kowal, G. Arras, M. Colombo, M. Jouve, J. P. Morath et al., Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes, Proceedings of the National Academy of Sciences, vol.113, issue.8, pp.E968-E977, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02450678

J. P. Tosar and A. Cayota, Extracellular tRNAs and tRNA-derived fragments, RNA Biology, vol.17, issue.8, pp.1149-1167, 2020.

Y. Matsuno, T. Kanke, N. Maruyama, W. Fujii, K. Naito et al., Characterization of mRNA profiles of the exosome-like vesicles in porcine follicular fluid, PLoS ONE, vol.14, p.217760, 2019.

M. D. Locati, J. F. Pagano, G. Girard, W. A. Ensink, M. Van-olst et al., Expression of distinct maternal and somatic 5.8S, 18S, and 28S rRNA types during zebrafish development, RNA, vol.23, issue.8, pp.1188-1199, 2017.

M. Salhab, S. Dhorne-pollet, S. Auclair, C. Guyader-joly, D. Brisard et al., In vitro maturation of oocytes alters gene expression and signaling pathways in bovine cumulus cells, Molecular Reproduction and Development, vol.80, issue.2, pp.166-182, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01129702

D. Brisard, F. Chesnel, S. Elis, A. Desmarchais, L. Sánchez-lazo et al., Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism, Journal of Ovarian Research, vol.7, issue.1, p.44, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00995701

D. Brisard, A. Desmarchais, J. Touzé, L. Lardic, S. Freret et al., Alteration of energy metabolism gene expression in cumulus cells affects oocyte maturation via MOS?mitogen-activated protein kinase pathway in dairy cows with an unfavorable ?Fertil?? haplotype of one female fertility quantitative trait locus, Theriogenology, vol.81, issue.4, pp.599-612, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01129787

L. Sanchez-lazo, D. Brisard, S. Elis, V. Maillard, R. Uzbekov et al., Fatty Acid Synthesis and Oxidation in Cumulus Cells Support Oocyte Maturation in Bovine, Molecular Endocrinology, vol.28, issue.9, pp.1502-1521, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01129856

W. Tomek, H. Torner, and W. Kanitz, Comparative Analysis of Protein Synthesis, Transcription and Cytoplasmic Polyadenylation of mRNA during Maturation of Bovine Oocytes in vitro, Reproduction in Domestic Animals, vol.37, issue.2, pp.86-91, 2002.

P. Mermillod, R. Dalbis-tran, S. Uzbekova, A. Thlie, J. M. Traverso et al., Factors Affecting Oocyte Quality: Who is Driving the Follicle?, Reproduction in Domestic Animals, vol.43, pp.393-400, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02754681

S. Uzbekova, Y. Arlot-bonnemains, J. Dupont, R. Dalbiès-tran, P. Papillier et al., Spatio-Temporal Expression Patterns of Aurora Kinases A, B, and C and Cytoplasmic Polyadenylation-Element-Binding Protein in Bovine Oocytes During Meiotic Maturation1, Biology of Reproduction, vol.78, issue.2, pp.218-233, 2008.

A. Bettegowda and G. W. Smith, Mechanisms of maternal mRNA regulation: implications for mammalian early embryonic development, Frontiers in Bioscience, vol.12, issue.8-12, p.3713, 2007.

S. Roy, H. Y. Lin, C. Y. Chou, C. H. Huang, J. Small et al., Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity, International Journal of Molecular Sciences, vol.20, issue.6, p.1349, 2019.

C. Simon, D. W. Greening, D. Bolumar, N. Balaguer, L. A. Salamonsen et al., Extracellular vesicles in human reproduction in health and disease, Endocr Rev, vol.39, pp.292-332, 2018.