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EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty

Abstract : Among mouse mammary tumor models, syngeneic cell lines present an advantage for the study of immune response. However, few of these models are well characterized. The tumor line EO771 is derived from spontaneous breast cancer of C57BL/6 mice. These cells are widely used but are referenced under different names: EO771, EO 771, and E0771. The characteristics of the EO771 cells are well described but some data are contradictory. This cell line presents the great interest of developing an immunocompetent neoplastic model using an orthotopic implantation reflecting the mammary tumors encountered in breast cancer patients. This review presents the phenotype characteristics of EO771 and its sensitivity to nutrients and different therapies such as radiotherapy, chemotherapy, hormone therapy, and immunotherapy.
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https://hal.inrae.fr/hal-03019063
Contributor : Sabine Rossi <>
Submitted on : Wednesday, March 31, 2021 - 4:09:32 PM
Last modification on : Friday, June 4, 2021 - 3:54:02 PM

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Augustin Le Naour, Adrien Rossary, Marie-Paule Vasson. EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty. Cancer Medicine, Wiley, 2020, 9 (21), pp.8074-8085. ⟨10.1002/cam4.3295⟩. ⟨hal-03019063⟩

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