Finding new solutions to reduce the use of pesticides is a major challenge to move towards productive fruit orchards respectful of the environmentand human health. Breeding of new varieties naturally resistant to pathogens and pests has long been used, but the rapid overcome of geneticresistances is often observed. Induction of resistance by exogenous agents called Plant Resistance Inducers or PRI holds great potential for plantprotection, but their performance in the eld remains variable. The present project explores the added value of combining genetic and inducedresistances in apple for an efficient and sustainable control of apple scab (Venturia inaequalis)and re blight (Erwinia amylovora). For both diseases, protection tests were carried out on a F1 mapping progeny from the cross between two partially resistant genotypes, ‘TN10-8’ and‘Fiesta’, to evaluate the interaction between genetic resistances (QTLs) and PRI-induced resistance. The whole population (~260 individuals) wasphenotyped for scab and re blight resistance under articial inoculation performed two days after pretreatment with acibenzolar-S-methyl (Bion®,Syngenta; a salicylic acid analog) or water (control). The population was also genotyped with the Illumina 20K SNP array. The rst results support the hypothesis of an additive behavior when combining resistance QTLs and PRI effect. Five QTLs have been detected for scabresistance likewise for re blight. Most QTLs detected in PRI-treated population were detected in control population, and PRI treatment appears to onlyslightly modulate QTL allelic effects, except for one QTL in re blight. Molecular mechanisms involved in both, treated and untreated situations are under investigation thanks to gene expression (qPCR) and metabolomic(LC-MS) analyses to better characterize the combination of intrinsic (genetic) and induced resistance at various time after PRI-treatment andinoculation.