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Improving Short- and Long-Term Genetic Gain by Accounting for Within-Family Variance in Optimal Cross-Selection

Abstract : The implementation of genomic selection in recurrent breeding programs raises the concern that a higher inbreeding rate could compromise the long-term genetic gain. An optimized mating strategy that maximizes the performance in progeny and maintains diversity for long-term genetic gain is therefore essential. The optimal cross-selection approach aims at identifying the optimal set of crosses that maximizes the expected genetic value in the progeny under a constraint on genetic diversity in the progeny. Optimal cross-selection usually does not account for within-family selection, i.e., the fact that only a selected fraction of each family is used as parents of the next generation. In this study, we consider within-family variance accounting for linkage disequilibrium between quantitative trait loci to predict the expected mean performance and the expected genetic diversity in the selected progeny of a set of crosses. These predictions rely on the usefulness criterion parental contribution (UCPC) method. We compared UCPC-based optimal cross-selection and the optimal cross-selection approach in a long-term simulated recurrent genomic selection breeding program considering overlapping generations. UCPC-based optimal cross-selection proved to be more efficient to convert the genetic diversity into short-and long-term genetic gains than optimal cross-selection. We also showed that, using the UCPC-based optimal cross-selection, the long-term genetic gain can be increased with only a limited reduction of the short-term commercial genetic gain.
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https://hal.inrae.fr/hal-03111538
Contributor : Sandrine Fouché <>
Submitted on : Friday, January 15, 2021 - 1:08:48 PM
Last modification on : Tuesday, June 15, 2021 - 2:57:07 PM

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Antoine Allier, Christina Lehermeier, Alain Charcosset, Laurence Moreau, Simon Teyssèdre. Improving Short- and Long-Term Genetic Gain by Accounting for Within-Family Variance in Optimal Cross-Selection. Frontiers in Genetics, Frontiers, 2019, 10, ⟨10.3389/fgene.2019.01006⟩. ⟨hal-03111538⟩

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