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Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

Abstract : The antibodies of jawless vertebrates consist of leucine-rich repeat arrays encoded by somatically assembled VLRB genes. It is unknown how the incomplete germline VLRB loci are converted into functional antibody genes during B lymphocyte development in lampreys. In Lampetra planeri larvae lacking the cytidine deaminase CDA2 gene, VLRB assembly fails, whereas the T lineage-associated VLRA and VLRC antigen receptor gene assemblies occur normally. Thus, CDA2 acts in a B cell lineage-specific fashion to support the somatic diversification of VLRB antibody genes. CDA2 is closely related to activation-induced cytidine deaminase (AID), which is essential for the elaboration of immunoglobulin gene repertoires in jawed vertebrates. Our results thus identify a convergent mechanism of antigen receptor gene assembly and diversification that independently evolved in the two sister branches of vertebrates.
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https://hal.inrae.fr/hal-03137734
Contributor : Sophie Le Perchec <>
Submitted on : Wednesday, February 10, 2021 - 3:56:27 PM
Last modification on : Wednesday, August 4, 2021 - 4:12:06 PM

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Ryo Morimoto, Connor O’meara, Stephen Holland, Inês Trancoso, Ahmed Souissi, et al.. Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys. Science Immunology, American Association for the Advancement of Science, 2020, 5 (45), pp.eaba0925. ⟨10.1126/sciimmunol.aba0925⟩. ⟨hal-03137734⟩

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