Skip to Main content Skip to Navigation
Journal articles

Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts: novel insights from a bovine embryo-transfer model

Abstract : Study question: Does oocyte maturation under lipolytic conditions have detrimental carry-over effects on post-hatching embryo development of good-quality blastocysts after transfer? Summary answer: Surviving, morphologically normal blastocysts derived from bovine oocytes that matured under lipotoxic conditions exhibit long-lasting cellular dysfunction at the transcriptomic and metabolic levels, which coincides with retarded post-hatching embryo development. What is known already: There is increasing evidence showing that following maturation in pathophysiologically relevant lipotoxic conditions (as in obesity or metabolic syndrome), surviving blastocysts of good (transferable) morphological quality have persistent transcriptomic and epigenetic alteration even when in vitro embryo culture takes place under standard conditions. However, very little is known about subsequent development in the uterus after transfer.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03160654
Contributor : Isabelle Hue <>
Submitted on : Friday, March 5, 2021 - 1:51:17 PM
Last modification on : Thursday, September 9, 2021 - 4:15:25 PM

Links full text

Identifiers

Citation

Karolien Desmet, Waleed Marei, Christophe Richard, Katrien Sprangers, Gerrit Beemster, et al.. Oocyte maturation under lipotoxic conditions induces carryover transcriptomic and functional alterations during post-hatching development of good-quality blastocysts: novel insights from a bovine embryo-transfer model. Human Reproduction, Oxford University Press (OUP), 2020, 35 (2), pp.293-307. ⟨10.1093/humrep/dez248⟩. ⟨hal-03160654⟩

Share

Metrics

Record views

45