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                <title level="j">Le Point Vétérinaire (Éd. Expert rural)</title>
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                <term xml:lang="en">prevalence</term>
                <term xml:lang="en">Paratuberculosis</term>
                <term xml:lang="en">excretion</term>
                <term xml:lang="en">diagnosis</term>
                <term xml:lang="en">mycobacteria</term>
                <term xml:lang="fr">excrétion</term>
                <term xml:lang="fr">diagnostic</term>
                <term xml:lang="fr">prévalence</term>
                <term xml:lang="fr">mycobactérie</term>
                <term xml:lang="fr">Paratuberculose</term>
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              <p>Johne’s disease is a category 2 health risk (as indicated in French legislation) and is still very widespread among ruminants. It is a difficult disease to eradicate because of its specificity and control policies. Most analyses carried out today are ELISA tests, the result of which depends on the stage of the infection. It may become possible to detect sub-clinical cases with the development of novel tests. Promising leads include bacteriophage tests, interferon tests, transcriptomic analysis or Mycobacterium avium ssp. paratuberculosis protein microarray tests.</p>
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              <p>La paratuberculose, danger sanitaire de seconde catégorie, est une maladie encore très répandue chez les ruminants. Pour l’éradiquer, la difficulté tientà la fois à sa spécificité et aux politiques de contrôle. La plupart des analyses sont aujourd’hui réalisées par la méthode immuno-enzymatique Elisa, dont le résultat dépend du stade de l’infection. La détection de cas infracliniques pourrait devenir possible avec l’arrivée de nouveaux tests. Parmi les pistesprometteuses, citons les tests à bactériophages, à l’interféron, l’analyse transcriptomique ou encore les puces à protéines de Mycobacterium avium ssp.paratuberculosis.</p>
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