Farm animals may develop close relationship to humans, which is intrinsically linked to their cognitive abilities in terms of perception, understanding and use of human signals, memory and learning. Recent studies focused on mutual use of acoustic signals (human voice and animals vocalisations) for the development of human-animal relationship, and the properties that those signals may have for the other species. Farm animals are able to discriminate human voices, according to their physical characteristics, and use them to adapt their behaviour and vocalisations. In this sense, human voice seems important for animals needs. To some extend human voice might also acquire an informative value. Prenatally, human voice is used for discriminative learning, which helps newborns to adapt to new environments. Human also use animal vocalisations. The emotional content of vocalisations is discriminated and recognized by humans. Vocalisations in presence of familiar and unfamiliar humans differ from those directed to conspecifics in anticipatory tasks. Vocalisations seems to be a potential way for animals to directly communicate their needs and emotions to humans, the communicative rules remaining to be determined. Human acoustic communication, from the prenatal stage should therefore be used in farms to develop positive relationship with humans, taking into account animals perception and memory. Farmer should also be trained to recognize vocal signals of their animals, helping them to adapt their management strategies and favour the ones with positive outcomes.