Skip to Main content Skip to Navigation
Journal articles

Human T-Lymphotropic Virus type 1c subtype proviral loads, chronic lung disease and survival in a prospective cohort of Indigenous Australians

Abstract : Background The Human T-Lymphotropic Virus type 1c subtype (HTLV-1c) is highly endemic to central Australia where the most frequent complication of HTLV-1 infection in Indigenous Australians is bronchiectasis. We carried out a prospective study to quantify the prognosis of HTLV-1c infection and chronic lung disease and the risk of death according to the HTLV-1c proviral load (pVL). Methodology/Principal findings 840 Indigenous adults (discharge diagnosis of bronchiectasis, 154) were recruited to a hospital-based prospective cohort. Baseline HTLV-1c pVL were determined and the results of chest computed tomography and clinical details reviewed. The odds of an association between HTLV-1 infection and bronchiectasis or bronchitis/bronchiolitis were calculated, and the impact of HTLV-1c pVL on the risk of death was measured. Radiologically defined bronchiectasis and bronchitis/bronchiolitis were significantly more common among HTLV-1-infected subjects (adjusted odds ratio = 2.9; 95% CI, 2.0, 4.3). Median HTLV-1c pVL for subjects with airways inflammation was 16-fold higher than that of asymptomatic subjects. There were 151 deaths during 2,140 person-years of follow-up (maximum follow-up 8.13 years). Mortality rates were higher among subjects with HTLV-1c pVL !1000 copies per 10 5 peripheral blood leukocytes (log-rank χ 2 (2df) = 6.63, p = 0.036) compared to those with lower HTLV-1c pVL or uninfected subjects. Excess mortality was largely due to bronchiectasis-related deaths (adjusted HR 4.31; 95% CI, 1.78, 10.42 versus uninfected).
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03183807
Contributor : Jocelyn Turpin <>
Submitted on : Sunday, March 28, 2021 - 11:50:38 PM
Last modification on : Wednesday, June 2, 2021 - 4:27:27 PM

File

2018_pntd_Einsiedel.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Lloyd Einsiedel, Pham Hai, Wilson Kim, Walley Rebecca, Jocelyn Turpin, et al.. Human T-Lymphotropic Virus type 1c subtype proviral loads, chronic lung disease and survival in a prospective cohort of Indigenous Australians. PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (3), pp.e0006281. ⟨10.1371/journal.pntd.0006281⟩. ⟨hal-03183807⟩

Share

Metrics

Record views

3

Files downloads

5