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Adipose Tissue Properties in Tumor-Bearing Breasts

Abstract : The tissue stroma plays a major role in tumors' natural history. Most programs for tumor progression are not activated as cell-autonomous processes but under the conditions of cross-talks between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares adipose tissues in tumor-bearing breasts to those in tumor-free breasts with the intention of defining a signature that could translate into markers of cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 137 genes of which a significant fraction belongs to inflammation, integrin and wnt signaling pathways. These observations show that adipose tissues from tumor-bearing breasts have a distinct physiological status from those from tumor-free breasts. We propose that this constitutive status contributes as a non-cell autonomous process to determine permissiveness for tumor growth.
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Contributor : Dominique l'Hostis <>
Submitted on : Tuesday, March 30, 2021 - 10:27:40 AM
Last modification on : Thursday, April 8, 2021 - 11:49:18 AM

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Isabelle Miran, Dominique Scherer, Pauline Ostyn, Chafika Mazouni, Françoise Drusch, et al.. Adipose Tissue Properties in Tumor-Bearing Breasts. Frontiers in Oncology, Frontiers, 2020, 10, ⟨10.3389/fonc.2020.01506⟩. ⟨hal-03185087⟩



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