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The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

Abstract : Highlights d The 7SK snRNA is dispensable for cell proliferation under standard growth conditions d After UV exposure, 7SK/P-TEFb is needed for proper stress response and cell survival d P-TEFb extracted from 7SK/P-TEFb triggers UV-induced general RNAPII pause release d P-TEFb from 7SK/P-TEFb supports activation of important UV-responsive genes
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https://hal.inrae.fr/hal-03204450
Contributor : Hélène Lesur <>
Submitted on : Wednesday, April 21, 2021 - 3:15:21 PM
Last modification on : Monday, July 26, 2021 - 3:10:28 PM

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Cécilia Studniarek, Michael Tellier, Pascal G.P. Martin, Shona Murphy, Tamás Kiss, et al.. The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming. Cell Reports, Elsevier Inc, 2021, 35 (2), pp.108965. ⟨10.1016/j.celrep.2021.108965⟩. ⟨hal-03204450⟩

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