In this perspective, we describe how the link removal (LR) analysis in social complex networks may be a promising tool to model non-pharmaceutical interventions (NPIs) and social distancing to prevent epidemics spreading. First, we show how the extent of the epidemic spreading and NPIs effectiveness over complex social networks may be evaluated with a static indicator, that is, the classic largest connected component (LCC). Then we explain how coupling the LR analysis and type SIR epidemiological models (EM) provide further information by including the temporal dynamics of the epidemic spreading. This is a promising approach to investigate important aspects of the recent NPIs applied by government to contain SARS-CoV-2, such as modeling the effect of the social distancing severity and timing over different network topologies. Further, implementing different link removal strategies to halt epidemics spreading provides information to individuate more effective NPIs, representing an important tool to offer a rationale sustaining policies to prevent SARS-CoV-2 and similar epidemics.