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Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.

Abstract : We investigated the transcriptional regulation of cytochrome P450 1A1 (CYP1A1) gene in human lymphoblastoid B cells and report that a high inducibility of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is associated with glutathione S-transferase M1 (GSTM1) null genotype, whereas the presence of at least one GSTM1 allele is correlated with induction of only low levels of CYP1A1 mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin. These data underline the major importance of the CYP1A1 inducibility phenotype associated with the homozygous GSTM1 null genotype in chemically induced cancers.
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https://hal.inrae.fr/hal-03271258
Contributor : Pierre de Coppet Connect in order to contact the contributor
Submitted on : Friday, June 25, 2021 - 3:06:32 PM
Last modification on : Tuesday, September 28, 2021 - 5:14:53 PM

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  • HAL Id : hal-03271258, version 1
  • PUBMED : 7585625

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C Vaury, R Lainé, P Noguiez, Pierre de Coppet, C Jaulin, et al.. Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.. Cancer Research, American Association for Cancer Research, 1995, 55 (23), pp.5520-3. ⟨hal-03271258⟩

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