Skip to Main content Skip to Navigation
Journal articles

Integrative biology defines novel biomarkers of resistance to strongylid infection in horses

Abstract : The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential. To date, this has been missing in livestock species. Here, we selected Welsh ponies with divergent intrinsic susceptibility (measured by their egg excretion levels) to cyathostomin infection and found that their divergence was sustained across a 10-year time window. Using this unique set of individuals, we monitored variations in their blood cell populations, plasma metabolites and faecal microbiota over a grazing season to isolate core differences between their respective responses under worm-free or natural infection conditions. Our analyses identified the concomitant rise in plasma phenylalanine level and faecal Prevotella abundance and the reduction in circulating monocyte counts as biomarkers of the need for drug treatment (egg excretion above 200 eggs/g). This biological signal was replicated in other independent populations. We also unravelled an immunometabolic network encompassing plasma beta-hydroxybutyrate level, short-chain fatty acid producing bacteria and circulating neutrophils that forms the discriminant baseline between susceptible and resistant individuals. Altogether our observations open new perspectives on the susceptibility of equids to strongylid infection and leave scope for both new biomarkers of infection and nutritional intervention.
Complete list of metadata

https://hal.inrae.fr/hal-03284457
Contributor : Nathalie Katy Chanteloup <>
Submitted on : Monday, July 12, 2021 - 3:47:20 PM
Last modification on : Saturday, September 11, 2021 - 3:45:48 AM

File

2021_Salle_Scientific-Reports_...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Guillaume Salle, Cécile Canlet, Jacques Cortet, Christine Koch, Joshua Malsa, et al.. Integrative biology defines novel biomarkers of resistance to strongylid infection in horses. Scientific Reports, Nature Publishing Group, 2021, 11 (1), 15 p. ⟨10.1038/s41598-021-93468-2⟩. ⟨hal-03284457⟩

Share

Metrics

Record views

106

Files downloads

85