Skip to Main content Skip to Navigation
Journal articles

Next‐generation biological control: the need for integrating genetics and genomics

Kelley Leung 1, * Erica Ras 2 Kim Ferguson 3 Simone Ariëns 4 Dirk Babendreier 5 Piter Bijma 3 Kostas Bourtzis 2 Jacques Brodeur 6 Margreet Bruins 3 Alejandra Centurión 4 Sophie Chattington 4 Milena Chinchilla‐ramírez 7 Marcel Dicke 3 Nina Fatouros 3 Joel González‐cabrera 8 Thomas Groot 9 Tim Haye 5 Markus Knapp 9 Panagiota Koskinioti 2 Sophie Le Hesran 3, 9 Manolis Lyrakis 10, 11 Angeliki Paspati 7 Meritxell Pérez‐hedo 7 Wouter Plouvier 12 Christian Schlötterer 13 Judith Stahl 5, 14 Andra Thiel 15 Alberto Urbaneja 7 Louis Zande 1 Eveline Verhulst Louise Vet 3 Sander Visser 16, 17 John Werren 18 Shuwen Xia 3 Bas Zwaan 3 Sara Magalhães 19 Leo Beukeboom 20 Bart Pannebakker 3
Abstract : Biological control is widely successful at controlling pests, but effective biocontrol agents are now more difficult to import from countries of origin due to more restrictive international trade laws (the Nagoya Protocol). Coupled with increasing demand, the efficacy of existing and new biocontrol agents needs to be improved with genetic and genomic approaches. Although they have been underutilised in the past, application of genetic and genomic techniques is becoming more feasible from both technological and economic perspectives. We review current methods and provide a framework for using them. First, it is necessary to identify which biocontrol trait to select and in what direction. Next, the genes or markers linked to these traits need be determined, including how to implement this information into a selective breeding program. Choosing a trait can be assisted by modelling to account for the proper agro-ecological context, and by knowing which traits have sufficiently high heritability values. We provide guidelines for designing genomic strategies in biocontrol programs, which depend on the organism, budget, and desired objective. Genomic approaches start with genome sequencing and assembly. We provide a guide for deciding the most successful sequencing strategy for biocontrol agents. Gene discovery involves quantitative trait loci analyses, transcriptomic and proteomic studies, and gene editing. Improving biocontrol practices includes marker-assisted selection, genomic selection and microbiome manipulation of biocontrol agents, and monitoring for genetic variation during rearing and post-release. We conclude by identifying the most promising applications of genetic and genomic methods to improve biological control efficacy.
Complete list of metadata

https://hal.inrae.fr/hal-03284683
Contributor : Roselyne Tâche <>
Submitted on : Monday, July 12, 2021 - 5:27:58 PM
Last modification on : Tuesday, July 13, 2021 - 3:38:18 AM

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Links full text

Identifiers

Collections

Citation

Kelley Leung, Erica Ras, Kim Ferguson, Simone Ariëns, Dirk Babendreier, et al.. Next‐generation biological control: the need for integrating genetics and genomics. Biological Reviews, Wiley, 2020, 95 (6), pp.1838-1854. ⟨10.1111/brv.12641⟩. ⟨hal-03284683⟩

Share

Metrics

Record views

26