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Evolution of master sex determiners: TGF-β signalling pathways at regulatory crossroads

Abstract : To date, more than 20 different vertebrate master sex-determining genes have been identified on different sex chromosomes of mammals, birds, frogs and fish. Interestingly, six of these genes are transcription factors ( Dmrt1 - or Sox3 - related) and 13 others belong to the TGF-β signalling pathway ( Amh , Amhr2 , Bmpr1b , Gsdf and Gdf6 ). This pattern suggests that only a limited group of factors/signalling pathways are prone to become top regulators again and again. Although being clearly a subordinate member of the sex-regulatory network in mammals, the TGF-β signalling pathway made it to the top recurrently and independently. Facing this rolling wave of TGF-β signalling pathways, this review will decipher how the TGF-β signalling pathways cope with the canonical sex gene regulatory network and challenge the current evolutionary concepts accounting for the diversity of sex-determining mechanisms. This article is part of the theme issue ‘Challenging the paradigm in sex chromosome evolution: empirical and theoretical insights with a focus on vertebrates (Part I)’.
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https://hal.inrae.fr/hal-03289911
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Submitted on : Monday, July 19, 2021 - 9:42:43 AM
Last modification on : Friday, September 17, 2021 - 8:24:01 PM

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Qiaowei Pan, Tomas Kay, Alexandra Depincé, Mateus Adolfi, Manfred Schartl, et al.. Evolution of master sex determiners: TGF-β signalling pathways at regulatory crossroads. Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2021, 376 (1832), pp.20200091. ⟨10.1098/rstb.2020.0091⟩. ⟨hal-03289911⟩

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