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Accumulation of short-, medium-, and long-chain chlorinated paraffins in tissues of laying hens after dietary exposure

Abstract : Reliable human health risk assessment associated with chlorinated paraffins (CPs) exposure is limited by the lack of data on the fate of this complex family of contaminants. To gain knowledge on the accumulation and distribution of CPs in biota after ingestion, laying hens were dietary exposed to technical mixtures of short- (SCCPs), medium- (MCCPs), or long-chain (LCCPs) CPs of various chlorine contents during 91 days, at 200 ng/g of feed, each. Adipose tissue, liver, muscle and serum were collected at the steady-state, along with excreta. All C10-C36 CPs were detected in liver. However, differences were observed in CP distribution: LCCPs high %Cl were retained in the liver; LCCPs low %Cl circulated through the serum and were distributed in the different compartments, but were mostly excreted through the eggs; SCCPs and MCCPs were found in all tissues at similar levels. Finally, a mass balance indicated a potential for biotransformation.
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https://hal.inrae.fr/hal-03292414
Contributor : Elisabeth Baeza Connect in order to contact the contributor
Submitted on : Tuesday, July 20, 2021 - 2:23:44 PM
Last modification on : Tuesday, September 21, 2021 - 3:08:15 PM

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Marie Mézière, Philippe Marchand, Frédéric Larvor, Elisabeth Baéza, Bruno Le Bizec, et al.. Accumulation of short-, medium-, and long-chain chlorinated paraffins in tissues of laying hens after dietary exposure. Food Chemistry, Elsevier, 2021, 351, pp.1-9. ⟨10.1016/j.foodchem.2021.129289⟩. ⟨hal-03292414⟩

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