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Coronavirus entry: how we arrived at SARS-CoV-2

Abstract : Because of the COVID-19 pandemic, the novel coronavirus SARS-CoV-2 has risen to shape scientific research during 2020, with its spike (S) protein being a predominant focus. The S protein is likely the most complicated of all viral glycoproteins and is a key factor in immunological responses and virus pathogenesis. It is also the driving force dictating virus entry mechanisms, which are highly ‘plastic’ for coronaviruses, allowing a plethora of options for different virus variants and strains in different cell types. Here we review coronavirus entry as a foundation for current work on SARS-CoV-2. We focus on the post-receptor binding events and cellular pathways that direct the membrane fusion events necessary for genome delivery, including S proteolytic priming and activation. We also address aspects of the entry process important for virus evolution and therapeutic development.
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Submitted on : Thursday, August 12, 2021 - 3:04:24 PM
Last modification on : Saturday, August 14, 2021 - 3:25:02 AM


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Gary Whittaker, Susan Daniel, Jean Millet. Coronavirus entry: how we arrived at SARS-CoV-2. Current Opinion in Virology, Elsevier, 2021, 47, pp.113-120. ⟨10.1016/j.coviro.2021.02.006⟩. ⟨hal-03319565⟩



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