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Absence of association between inflammatory dietary pattern and low trauma fractures: Results of the French cohort NutriNet-Santé

Julia Herrou 1, * Chantal Julia 2 Emmanuelle Kesse-Guyot 3 Mathilde Touvier 3 Serge Hercberg 2 Christian Roux 2 Karine Briot 2
* Corresponding author
2 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
Université Sorbonne Paris Nord, CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
Abstract : Introduction: The aim of our study was to assess the association between the Alternate Dietary Inflammatory Index (ADII) and the risk of fracture in a French cohort of women and men older than 50 years. Methods: A total of 15,096 participants were included from the French NutriNet-Sante cohort. The ADII score was calculated at inclusion. Incident low trauma fractures were retrospectively self-reported by participants on a specific additional questionnaire. Multivariate hazard ratio obtained from Cox proportional hazard regression models were used to characterize an association between ADII (in quartiles) and incident low trauma fractures. Results: In all, 12,046 participants (7607 (63.2%) women and 4439 (36.8%) men) were included in our study. For fractures, 806 (10.6%) and 191 (4.3%) low trauma fractures were recorded respectively in women and in men. Mean ADII was -1.23 (+/- 3.13) for women and -0.87 (+/- 3.64) for men. No association was detected between the ADII score and the risk of vertebral fracture (P = 0.21), major osteoporotic fracture (P = 0.93) and any low trauma fracture (P = 0.72) in women nor in men (P = 0.06 for major fracture and P = 0.10 for low trauma fracture) after adjustment for sociodemographic, lifestyle variables and for bone treatments. Conclusion: This study in postmenopausal women and men older than 50 years from the general population did not show any association between inflammatory dietary pattern measured using the ADII and the risk of incident low trauma fracture. (c) 2020 Societe francaise de rhumatologie.
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Submitted on : Monday, September 13, 2021 - 10:15:42 AM
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Julia Herrou, Chantal Julia, Emmanuelle Kesse-Guyot, Mathilde Touvier, Serge Hercberg, et al.. Absence of association between inflammatory dietary pattern and low trauma fractures: Results of the French cohort NutriNet-Santé. Joint Bone Spine, Elsevier Masson, 2020, 87 (6), pp.632-639. ⟨10.1016/j.jbspin.2020.05.013⟩. ⟨hal-03341964⟩

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