Microalgae are considered potential candidates in biorefinery processes, and due to their biochemical properties, they can be used in the production of biofuels such as biogas, as well as for bioremediation of liquid effluents. The objective of this review is to study the current status of microalgae anaerobic digestion and agricultural uses (as bio-stimulants and biofertilizers), starting from microalgae cultivation. Indeed, the efficiency of these processes necessarily depends on the evaluation of different biotic and abiotic factors that affect the growth of microalgae. However, the adaptation and the optimization of process parameters on a large scale is also limited by energy and economic constraints. Moreover, the integration of biogas production processes with microalgae cultivation allows a nutrients and CO 2 virtuous loop, thus promoting the sustainability of the process. Finally, this paper provides a general overview of biogas and biofertilizers production combination, as well as the related challenges and recommended future research perspectives to complement the gap in the literature.