Neurodevelopment vs. the immune system: Complementary contributions of maternally-inherited gene transcripts and proteins to successful embryonic development in fish - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Genomics Year : 2021

Neurodevelopment vs. the immune system: Complementary contributions of maternally-inherited gene transcripts and proteins to successful embryonic development in fish

Abstract

The aim of this study was to investigate the respective contribution of maternally-inherited mRNAs and proteins to egg molecular cargo and to its developmental competence in fish using pikeperch as a model. Our study provides novel insights into the understanding of type-specific roles of maternally-inherited molecules in fish. Here we show, for the first time, that transcripts and proteins have distinct, yet complementary, functions in the egg of teleost fish. Maternally-inherited mRNAs would shape embryo neurodevelopment, while maternally-inherited proteins would rather be responsible for protecting the embryo against pathogens. Additionally, we observed that processes directly preceding ovulation may considerably affect the reproductive success by modifying expression level of genes crucial for proper embryonic development, being novel fish egg quality markers (e.g., smarca4 or h3f3a). These results are of major importance for understanding the influence of external factors on reproductive fitness in both captive and wild-type fish species.
Fichier principal
Vignette du fichier
hal-03342588.pdf (1.09 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

Dates and versions

hal-03342588 , version 1 (16-01-2023)
hal-03342588 , version 2 (05-09-2023)

Licence

Attribution

Identifiers

Cite

Daniel Żarski, Aurelie Le Cam, Thomas Frohlich, Miwako Kösters, Christophe C. Klopp, et al.. Neurodevelopment vs. the immune system: Complementary contributions of maternally-inherited gene transcripts and proteins to successful embryonic development in fish. Genomics, 2021, 113 (6), pp.3811-3826. ⟨10.1016/j.ygeno.2021.09.003⟩. ⟨hal-03342588v2⟩
79 View
39 Download

Altmetric

Share

Gmail Facebook X LinkedIn More