Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2021

Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection

Résumé

Gastrointestinal nematodes (GIN) are an important constraint in small ruminant production. Genetic selection for resistant animals is a potential sustainable control strategy. Advances in molecular genetics have led to the identification of several molecular genetic markers associated with genes affecting economic relevant traits. In this study, the variants in the genome of Creole goats resistant or susceptible to GIN were discovered from RNAsequencing. We identified SNPs, insertions and deletions that distinguish the two genotypes, resistant and susceptible and we characterized these variants through functional analysis. The T cell receptor signalling pathway was one of the top significant pathways that distinguish the resistant from the susceptible genotype with 78% of the genes involved in this pathway showing genomic variants. These genomic variants are expected to provide useful resources especially for molecular breeding for GIN resistance in goats.
Fichier principal
Vignette du fichier
Aboshady_Plos1_2021.pdf (2.12 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03534329 , version 1 (19-01-2022)

Licence

Paternité

Identifiants

Citer

Hadeer M Aboshady, Nathalie Mandonnet, Anna M Johansson, Elisabeth Jonas, Jean-Christophe Bambou. Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection. PLoS ONE, 2021, 16, ⟨10.1371/journal.pone.0248405⟩. ⟨hal-03534329⟩
24 Consultations
13 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More