This paper presents the ANUMAB project-"Approches numériques et mathématiques appliquées pour la bioéconomie et la REUSE". This project, under the patronage of the UNESCO International Water Center ICIREWARD in Montpellier aims at i) proposing the creation of a UNESCO chair on the valorization of wastewater, waste and nutrients at ENIT-LAMSIN, Tunisia, ii) creating a new research theme within the SIMEV UNESCO chair in Montpellier and iii) beginning research activities through the reinforcement of collaborations by relying on the network of collaborations federated within the Euro-Mediterranean research network TREASURE-"Treatment and sustainable reuse of wastewater in the Mediterranean rim". The main originality of the project lies in the fact that it advocates the adoption of an integrated multidisciplinary approach to meet the challenges of the circular economy.