Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Clinical and Diagnostic Laboratory Immunology Year : 1994

Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis

P Vannuffel
  • Function : Author
C Dieterich
  • Function : Author
B Naerhuyzen
  • Function : Author
M Coene
  • Function : Author
R Fiasse
  • Function : Author
C Cocito
  • Function : Author

Abstract

Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.

Dates and versions

hal-03672668 , version 1 (19-05-2022)

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P Vannuffel, C Dieterich, B Naerhuyzen, P Gilot, M Coene, et al.. Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis. Clinical and Diagnostic Laboratory Immunology, 1994, 1 (2), pp.241-243. ⟨10.1128/cdli.1.2.241-243.1994⟩. ⟨hal-03672668⟩

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