The #OFE2021 conference “Farmer-centric On-Farm Experimentation—Digital Tools for a Scalable Transformative Pathway” was organised by INRAE-#DigitAg and the ISPA OFE-C (International Society of Precision Agriculture, On-Farm Experimentation Community). #OFE2021 was conducted in a hybrid format from October 13th to 15th in Montpellier (including one day dedicated to a workshop to develop policy propositions) and was preceded by a round of 4 webinars in May 2021 on 4 major themes for OFE Value creation, People and processes, Data analytics, and Policy linkages. Most of the 170 participants (40 people in Montpellier and 140 on-line) were researchers but also representatives from farmers’ associations, startups, NGOs, and policymakers. The conference achieved good geographical representation with 36 countries (54% from Europe, 16% from North America, 8% from South America, 8% from Asia, 8% from Africa and 6% from Oceania). The conference was structured around invited speakers addressing the 4 above-mentioned themes as well as 4-minutes videos/presentations, that were presented either as flashes or on the website only (as an alternative to traditional posters). This gave birth to a very rich and diversified scientific production. In total, 80 submissions were selected (30 papers and 50 short presentations). The present Proceedings have been built in an original multimedia format which gathers all the contributions that have been produced for the conference : pre-conference webinars, contributions of the invited speakers and of researchers who answered the call for papers and videos.