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Identification of genome regions and promising candidate genes linked to innate immune capacity on young Holstein calves

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Abstract

In order to investigate the genomic control of innate immune response, the concentration levels of 14 cytokines produced naturally or in response to whole blood stimulation with three pattern recognition receptors agonists were determined in 623 Holstein calves enrolled in the Healthycalf project. The effect of the immunostimulants and the relationship among the cytokines produced were observed through a principal components analysis, and 50K GWAS were performed on all cytokine x condition traits. Results showed that most cytokines are oriented together following the first component that explained 70% of the variability and partially discriminated the agonistic conditions. Additionally, 40 genome regions were found in association with at least one trait with some regions being largely shared between conditions and cytokines. Seven positional candidate genes were considered as especially interesting due to their functional link to innate immune response reported from the literature.
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Dates and versions

hal-03731335 , version 1 (20-07-2022)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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P Martin, S Fresco, L Jouneau, S Taussat, A Vinet, et al.. Identification of genome regions and promising candidate genes linked to innate immune capacity on young Holstein calves. 12th World Congress on Genetics Applied to Livestock Production, Jul 2022, Rotterdam, Netherlands. ⟨10.15454/1.5483257052131956E12⟩. ⟨hal-03731335⟩
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