Sequence-based GWAS meta-analyses for beef production traits
Résumé
Five partners of the H2020 BovReg project have performed sequence-based GWAS for 28 beef production traits (4 growth, 9 morphology, and/or 15 carcass traits) using 54,782 animals from 15 different purebred or crossbred cattle populations. These results were herein combined to conduct 16 different meta-analyses (MA) with both the z-score and the fixed effects MA methods. We identified QTL in 15 MA on BTA2, 5, 6, 7, 10, 11, 13, 14, 15, 17, and 20, most of them being common to several MA. Overall, the fixed effects method outperformed the zscore method in terms of significance level and number of QTL detected. Compared to withinpopulation GWAS, MA found a higher number of QTL in which variants were more frequently located in genes (e.g. MSTN, LCORL, ARRDC3, PLAG1, COL3A1).
Domaines
Génétique animale
Origine : Fichiers produits par l'(les) auteur(s)