Detailed analysis of mortality rates in the female progeny of Holstein bulls allows the discovery of new dominant genetic defects
Résumé
We analyzed juvenile mortality rates per sire family for four different periods in a population of Holstein heifers born between 2017 and 2020 in France and Wallony. The global mortality rate from birth to one year of life was 11.8% in the population of 1,001 sires, while it reached 30.6% and 19.9% in the progeny of two bulls, Mo and Pa, respectively. Various investigations were carried out on these two bulls and their progeny, including clinical examination, karyotyping, genetic mapping, and whole genome sequencing. Mo was found to carry a partial translocation from BTA29 to BTA26 while Pa was mosaic for a dominant nonsense mutation in the GATA6 gene causing cardiac outflow tract defect in its progeny.
Domaines
Génétique animale
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