Normal and Pathological NRF2 Signalling in the Central Nervous System - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Antioxidants Année : 2022

Normal and Pathological NRF2 Signalling in the Central Nervous System

Résumé

The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master regulator of antioxidant cellular response, but in the time since, numerous important biological functions linked to cell survival, cellular detoxification, metabolism, autophagy, proteostasis, inflammation, immunity, and differentiation have been attributed to this pleiotropic transcription factor that regulates hundreds of genes. After 40 years of in-depth research and key discoveries, NRF2 is now at the center of a vast regulatory network, revealing NRF2 signalling as increasingly complex. It is widely recognized that reactive oxygen species (ROS) play a key role in human physiological and pathological processes such as ageing, obesity, diabetes, cancer, and neurodegenerative diseases. The high oxygen consumption associated with high levels of free iron and oxidizable unsaturated lipids make the brain particularly vulnerable to oxidative stress. A good stability of NRF2 activity is thus crucial to maintain the redox balance and therefore brain homeostasis. In this review, we have gathered recent data about the contribution of the NRF2 pathway in the healthy brain as well as during metabolic diseases, cancer, ageing, and ageing-related neurodegenerative diseases. We also discuss promising therapeutic strategies and the need for better understanding of cell-type-specific functions of NRF2 in these different fields.
Fichier principal
Vignette du fichier
heurtaux_2022_vol11_1426_antioxidants.pdf (1.31 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-03744948 , version 1 (03-08-2022)

Licence

Paternité

Identifiants

Citer

Tony Heurtaux, David S. Bouvier, Alexandre Benani, Sergio Helgueta Romero, Katrin B. M. Frauenknecht, et al.. Normal and Pathological NRF2 Signalling in the Central Nervous System. Antioxidants , 2022, 11 (8), pp.1426. ⟨10.3390/antiox11081426⟩. ⟨hal-03744948⟩
13 Consultations
81 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More