Nutraceuticals help prevent various metabolic disorders such as those related to metabolic syndrome (MetS). The latter is generally caused by a sedentary lifestyle and the consumption of ultra-processed products [1] [2]. Here, we evaluated the beneficial effects of a nutritional mixture based on Berberine and Citrus (Citrus pericarp-35% bioflavonoids-aqueous extraction) and Apple (phloridzin-5%-hydro-ethanolic extraction) (BCA) extracts in a rat model of MetS. Thirty-two 8-week-old Wistar rats were randomly divided into 4 groups: untreated control (U-C;n=8), BCA-treated control (T-C;n=8), untreated rats fed with High Fat High Sugar Diet (HFHS) (U-HFHS;n=8) and BCA-treated rats fed with HFHS diet (T-HFHS;n=8). All rats received daily water or BCA mixture (100mg/kg po) for 13 weeks. Morphological and metabolic parameters were measured at the beginning and the end of the treatment. Concentration-relaxation curves to insulin and acetylcholine were also determined on isolated thoracic aorta. Compared with the control group, rats fed with HFHS showed an increase in body weight, abdominal circumference, and adiposity index calculated from perirenal and peri-epididymal fat (P<0.001). The HFHS diet induced atrophy of the ceacum (P<0.001). The BCA treatment did not modify weight gain or food intake but significantly decreased visceral fat weight (Figure 1) and reduced ceacal atrophy (P<0.01) compared to the HFHS untreated group. Relaxing effects to acetylcholine showed no difference between the four groups. By contrast, in the HFHS-fed group, insulin-mediated relaxation was slightly impaired and this impairment was counteracted by BCA treatment.