Bile Acids: Key Players in Inflammatory Bowel Diseases?

Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota–BA–host axis may influence digestive inflammation.

Mots clés

inflammatory bowel diseases gut microbiota bile acids microbiome holobiont

Domaines

Sciences du Vivant [q-bio]

Fichier principal

2022_Kriaa_MDPI Cells.pdf (898.1 Ko)

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Licence : CC BY - Paternité

Bérengère Casal : Connectez-vous pour contacter le contributeur

https://hal.inrae.fr/hal-03812120

Soumis le : mercredi 12 octobre 2022-14:33:40

Dernière modification le : jeudi 11 avril 2024-03:24:09

Archivage à long terme le : vendredi 13 janvier 2023-18:35:26

Dates et versions

hal-03812120 , version 1 (12-10-2022)

Licence

Paternité

Identifiants

HAL Id : hal-03812120 , version 1
DOI : 10.3390/cells11050901
PUBMED : 35269523
WOS : 000774925700001

Citer

Aicha Kriaa, Vincent Mariaule, Amin Jablaoui, Soufien Rhimi, Hela Mkaouar, et al.. Bile Acids: Key Players in Inflammatory Bowel Diseases?. Cells, 2022, 11 (5), pp.1-10. ⟨10.3390/cells11050901⟩. ⟨hal-03812120⟩

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INSERM AGROPARISTECH UNAM UNIV-PARIS-SACLAY INRAE GS-BIOSPHERA GS-LIFE-SCIENCES-HEALTH GS-HEALTH-DRUG-SCIENCES MICA-UNITES MICALIS ONIRIS

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