Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response - Archive ouverte HAL Access content directly
Journal Articles Gut microbes Year : 2021

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

(1) , (2) , (3) , (4) , (1)
1
2
3
4

Abstract

The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but somewhat interconnected significant immune pathways which play complex roles in a variety of physiological processes as well as pathological conditions. Aberrant activation of PI3K/Akt/mTOR signaling pathways has been reported to be associated in a wide variety of human diseases. Over the past few years, growing evidence in in vitro and in vivo models suggest that this sophisticated and subtle cascade mediates the orchestration of the immune response in health and disease through exposure to probiotics. An expanding body of literature has highlighted the contribution of probiotics and PI3K/Akt/mTOR signaling pathways in gastrointestinal disorders, metabolic syndrome, skin diseases, allergy, salmonella infection, and aging. However, longitudinal human studies are possibly required to verify more conclusively whether the investigational tools used to understand the regulation of these pathways might provide effective approaches in the prevention and treatment of various disorders. In this Review, we summarize the experimental evidence from recent peer-reviewed studies and provide a brief overview of the causal relationship between the effects of probiotics and their metabolites on the components of PI3K/Akt/mTOR signaling pathways and human disease.
Fichier principal
Vignette du fichier
2021_Mohseni_Gut Microbes.pdf (1.29 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-03824840 , version 1 (21-10-2022)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Amir Hossein Mohseni, Vincenzo Casolaro, Luis Bermúdez-Humarán, Hossein Keyvani, Sedigheh Taghinezhad-S. Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. Gut microbes, 2021, 13 (1), pp.1-18. ⟨10.1080/19490976.2021.1886844⟩. ⟨hal-03824840⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More