Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2022

Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia

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Abstract

Production of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution.
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hal-03830908 , version 1 (26-10-2022)

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Attribution - CC BY 4.0

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Olivier Kwiatek, Geneviève Libeau, Samia Guendouz, Chloé Corbanini, Andrey Gogin, et al.. Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia. Veterinary Research, 2022, 53 (1), pp.79. ⟨10.1186/s13567-022-01099-w⟩. ⟨hal-03830908⟩
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