Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization - Archive ouverte HAL Access content directly
Journal Articles Angiogenesis Year : 2022

Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization

(1, 2) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (1)
1
2

Abstract

Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts. We show here that overexpression of bioactive chemerin in mice results in a reduction of the density of the retinal vascular network during its development and in adults. Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning. This phenotype was reversed to normal in CMKLR1-deficient mice, demonstrating the role of this receptor. Chemerin inhibited also neoangiogenesis in a model of pathological proliferative retinopathy, and in response to hind-limb ischemia. Mechanistically, PTEN and FOXO1 antagonists could almost completely restore the density of the retinal vasculature, suggesting the involvement of the PI3-kinase/AKT pathway in the chemerin-induced vessel regression process.

Dates and versions

hal-03837047 , version 1 (02-11-2022)

Identifiers

Cite

Cyrine Ben Dhaou, Kamel Mandi, Mickaël Frye, Angela Acheampong, Ayoub Radi, et al.. Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization. Angiogenesis, 2022, 25 (2), pp.159-179. ⟨10.1007/s10456-021-09818-1⟩. ⟨hal-03837047⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More