Acute effects of different electroacupuncture point combinations to modulate the gut-brain axis in the minipig model - Archive ouverte HAL Access content directly
Journal Articles Evidence-Based Complementary and Alternative Medicine Year : 2022

Acute effects of different electroacupuncture point combinations to modulate the gut-brain axis in the minipig model

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Abstract

This study aimed to compare the gut-brain axis responses to acute electroacupuncture (EA) at di erent acupoint combinations in the minipig model. Four adult Yucatan minipigs were subjected twice to four acute EA treatments (25-minute acute sessions) including sham (false acupoints) and control (no EA), during anesthesia and according to a Latin-square design paradigm. Acupoint combinations (4 loci each) are head-abdomen (#70 Dafengmen, #35 Sanwan), back (bilateral #27 Pishu, #28 Weishu), leg (bilateral #79 Hangou, #63 Housanli), and sham (2 bilateral points that are not acupoints). Electrocardiograms were performed to explore heart rate variability (HRV). Infrared thermography was used to measure skin temperature at the stimulation points. Saliva (cortisol) and blood samples (leptin, total/active ghrelin, insulin, and glucose) were collected for further analyses before and after acute EA. All animals were also subjected to BOLD fMRI to investigate the brain responses to EA. Acute EA signi cantly modulated several physiological and metabolic parameters compared to basal, sham, and/or control conditions, with contrasting e ects in terms of BOLD responses in brain regions involved in the hedonic and cognitive control of food intake. e headabdomen combination appeared to be the most promising combination in terms of brain modulation of the corticostriatal circuit, with upregulation of the dorsolateral prefrontal cortex, dorsal striatum, and anterior cingulate cortex. It also induced signi cantly lower plasma ghrelin levels compared to sham, suggesting anorectic e ects, as well as no temperature drop at the stimulation site. is study opens the way to a further preclinical trial aimed at investigating chronic EA in obese minipigs.

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hal-03841724 , version 1 (07-11-2022)

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Attribution - CC BY 4.0

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Xuwen Zhang, Sylvie Guerin, Youenn Launay, Y. Serrand, Nicolas Coquery, et al.. Acute effects of different electroacupuncture point combinations to modulate the gut-brain axis in the minipig model. Evidence-Based Complementary and Alternative Medicine, 2022, 2022, pp.4384693. ⟨10.1155/2022/4384693⟩. ⟨hal-03841724⟩
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