Multi-objective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions - Archive ouverte HAL Access content directly
Journal Articles Journal of Applied Microbiology Year : 2023

Multi-objective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions

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Abstract

Aim: This study investigates the individual and combined effects of fermentation parameters for improving cell biomass productivity and the resistance to freezing, freeze-drying and freeze-dried storage of Lactobacillus delbrueckii subsp. bulgaricus CFL1. Methods and Results: Cells were cultivated at different temperatures (42°C and 37°C), pHs (5.8 and 4.8) and harvested at various growth phases (mid-exponential, deceleration and stationary growth phases). Specific acidifying activity was determined after fermentation, freezing, freeze-drying and freeze-dried storage. Multiple regression analyses were performed to identify the effects of fermentation parameters on the specific acidifying activity losses and to generate the corresponding 3D response surfaces. A multi-objective decision approach was applied to optimize biomass productivity and specific acidifying activity. The temperature positively influenced biomass
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hal-03951874 , version 1 (23-01-2023)

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Maria de L Tovilla-Coutiño, Stéphanie Passot, Ioan-Cristian Trelea, Marie-Hélène Ropers, Yann Gohon, et al.. Multi-objective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions. Journal of Applied Microbiology, 2023, pp.lxad003. ⟨10.1093/jambio/lxad003⟩. ⟨hal-03951874⟩
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