The enormous volume of blood ingested by hard ticks during their long attachment period is without a doubt the hallmark of their biology. Maintaining a homeostatic balance between ion and water intake and loss during their feeding is critical to preventing osmotic stress and death. Exactly 50 years ago, Kaufman and Phillips published a series of three consecutive papers on “Ion and water balance in the ixodid tick Dermacentor andersoni”, Journal of Experimental Biology (1973): I. Routes of ion and water excretion, 58: 523–36; II. Mechanism and control of salivary secretion 58: 537–547; and III. Influence of monovalent ions and osmotic pressure on salivary secretion 58: 549–564. This classic series significantly expanded our knowledge of the unique regulatory processes governing ion and water balance in fed ixodid ticks, highlighting its uniqueness among the blood-feeding arthropods. Their pioneer work had an enormous impact on understanding the vital role of salivary glands in these actions, and ultimately provided a consequential stepping stone for a new era of hard tick salivary gland physiological research.