Dedicated odor-taste stimulation design for fMRI flavor studies - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Neuroscience Methods Year : 2023

Dedicated odor-taste stimulation design for fMRI flavor studies


Background Flavor is a mental representation that results from the brain’s integration of at least odor and taste, and fMRI can highlight brain-related areas. However, delivering stimuli during fMRI can be challenging especially when administrating liquid stimuli in supine position. It remains unclear how and when odorants are released in the nose and how to improve odorant release. New method We used a proton transfer reaction mass spectrometer (PTR-MS) to monitor the in vivo release of odorants via the retronasal pathway during retronasal odor-taste stimulation in a supine position. We tested techniques to improve odorant release, including avoiding or delaying swallowing and velum open training (VOT). Results Odorant release was observed during retronasal stimulation, before swallowing, and in a supine position. VOT did not improve odorant release. Odorant release during stimulation had a latency more optimal for fitting with BOLD timing than after swallowing. Comparison with Existing Method(s) Previous in vivo measurements of odorant release under fMRI-like conditions showed that odorant release occurred only after swallowing. On the contrary, a second study found that aroma release could occur before swallowing, but participants were sitting. Conclusion Our method shows optimal odorant release during the stimulation phase, meeting the criteria for high-quality brain imaging of flavor processing without swallowing-related motion artifacts. These findings provide an important advancement in understanding the mechanisms underlying flavor processing in the brain.
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Dates and versions

hal-04101328 , version 1 (19-05-2023)



Marianela Santoyo-Zedillo, Isabelle Andriot, Géraldine Lucchi, Gustavo Pacheco-López, Héctor B. Escalona-Buendía, et al.. Dedicated odor-taste stimulation design for fMRI flavor studies. Journal of Neuroscience Methods, 2023, 393, pp.109881. ⟨10.1016/j.jneumeth.2023.109881⟩. ⟨hal-04101328⟩
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