French viticulture has been facing an estimated production decline of 5%, in average, per year for several years called "decline" (for "dépérissement"). This scourge is defined in relation to a multiyear decrease in grapevine productivity and/or premature, sudden or progressive death of the vine stock due to many causal factors that are still poorly understood. This decline is the subject of indepth studies at UMR SAVE, in particular the TraDéVi project (PNDV), aiming at analyzing this decrease in yield, partly due to biotic causes, including the major cryptogamic diseases and grapevine pests. The Grape Trunk Diseases (GTDs : Esca, Eutypiosis), first concerned, can lead to the death of the vine stocks, but are also monitored downy mildew, powdery mildew, grape berry moth, black rot and grey mould rot, which impact quality and yield. New indicators have been tested in order to better quantify this impact on yield, and to better establish relationships between multipathogens pressure, vegetative vigor and yield achievement (AIDB+, NDVI, YAR indicators, resp.). These indicators were analyzed on the basis of 2019 data in two regions, Cognac and Bordeaux. The two main indicators being of main interest and highlighted are (1) the AIDB+ multi-pathogens indicator and (2) the NDVIpass3-1 indicator relating to vigor loss due to dieback. A major result is to show that these indicators allowed us to quantify significantly the impact and harmfulness of GTDs on the grapevine and particularly on the yield achievement rate (YAR